利用逆转录病毒介导的基因转移进行艾滋病基因治疗，将HIV-1反义TAR和反式显性Rev蛋白基因传递给HIV-1感染的同卵双胞胎的同基因淋巴细胞。 - Suppr

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超能文献

Gene therapy for AIDS using retroviral mediated gene transfer to deliver HIV-1 antisense TAR and transdominant Rev protein genes to syngeneic lymphocytes in HIV-1 infected identical twins.

作者信息

Morgan R A, Walker R

出版信息

Hum Gene Ther. 1996 Jun 20;7(10):1281-306. doi: 10.1089/hum.1996.7.10-1281.

DOI:10.1089/hum.1996.7.10-1281

PMID:8793552

Abstract

摘要

相似文献

Gene therapy for AIDS using retroviral mediated gene transfer to deliver HIV-1 antisense TAR and transdominant Rev protein genes to syngeneic lymphocytes in HIV-1 infected identical twins.利用逆转录病毒介导的基因转移进行艾滋病基因治疗，将HIV-1反义TAR和反式显性Rev蛋白基因传递给HIV-1感染的同卵双胞胎的同基因淋巴细胞。

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Genetic instability of a MoMLV-based antisense double-copy retroviral vector designed for HIV-1 gene therapy.一种为HIV-1基因治疗设计的基于莫洛尼鼠白血病病毒（MoMLV）的反义双拷贝逆转录病毒载体的遗传不稳定性。

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Antisense-mediated inhibition of human immunodeficiency virus (HIV) replication by use of an HIV type 1-based vector results in severely attenuated mutants incapable of developing resistance.利用基于1型人类免疫缺陷病毒（HIV）的载体通过反义介导抑制HIV复制，会产生严重减毒的突变体，这些突变体无法产生耐药性。

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J Virol. 2001 Aug;75(16):7621-8. doi: 10.1128/JVI.75.16.7621-7628.2001.

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