泮托拉唑对苯妥英钠的药代动力学无影响。

No influence of pantoprazole on the pharmacokinetics of phenytoin.

作者信息

Middle M V, Müller F O, Schall R, Groenewoud G, Hundt H K, Huber R, Bliesath H, Steinijans V W

机构信息

FARMOVS Institute for Clinical Pharmacology and Drug Development, Department of Pharmacology, University of the Orange Free State, Bloemfontein, Republic of South Africa.

出版信息

Int J Clin Pharmacol Ther. 1996 May;34(1 Suppl):S72-5.

PMID:8793606

Abstract

Twenty-three healthy, male volunteers completed this doubleblind, randomized, placebo controlled, 2-period crossover study to assess the influence of multiple doses of pantoprazole on single-dose phenytoin pharmacokinetics. During each treatment period, the volunteers received either one 40 mg pantoprazole tablet or placebo for 7 days. In addition, a single-dose of 300 mg (3 x 100 mg capsules) phenytoin sodium was administered on day 4 of each treatment period. A 14-day wash-out period was allowed between phenytoin administrations. The results indicate that pantoprazole neither affects the rate nor the extent of absorption, nor the elimination of phenytoin.

摘要

23名健康男性志愿者完成了这项双盲、随机、安慰剂对照、两阶段交叉研究，以评估多剂量泮托拉唑对单剂量苯妥英药代动力学的影响。在每个治疗阶段，志愿者连续7天每日服用1片40mg泮托拉唑片或安慰剂。此外，在每个治疗阶段的第4天给予单剂量300mg（3×100mg胶囊）苯妥英钠。两次苯妥英给药之间有14天的洗脱期。结果表明，泮托拉唑既不影响苯妥英的吸收速率和程度，也不影响其消除。