Rukaria-Kaumbutho R M, Ojwang S B, Oyieke J B
Department of Obstetrics and Gynaecology, University of Nairobi, Kenya.
Int J Gynaecol Obstet. 1996 Jun;53(3):235-41. doi: 10.1016/0020-7292(96)02651-3.
The objective of the study was to determine the efficacy of chloroquine in pregnant women with Plasmodium falciparum parasitemia at therapeutic doses of 25 mg/kg body weight divided over 3 days.
Three-hundred pregnant women in Kilifi Hospital at the coast of Kenya were screened for malaria parasitemia using Giemsa stained thick blood smears. In vivo and in vitro parasite sensitivity to chloroquine was determined.
P. falciparum infections were present in 65 (22%) of 300 pregnant women. The in vivo tests showed that 46% of all the P. falciparum infections were resistant to chloroquine predominantly at RI and RII levels. The in vitro tests showed a resistance rate of 35%.
A large proportion of pregnant women with malaria do not respond to chloroquine therapy and alternative drugs are required.
本研究的目的是确定氯喹对体重25mg/kg、分3天服用的治疗剂量下患有恶性疟原虫血症的孕妇的疗效。
使用吉姆萨染色厚血涂片对肯尼亚海岸基利菲医院的300名孕妇进行疟疾寄生虫血症筛查。测定了寄生虫对氯喹的体内和体外敏感性。
300名孕妇中有65名（22%）感染了恶性疟原虫。体内试验表明，所有恶性疟原虫感染中有46%主要在RI和RII水平对氯喹耐药。体外试验显示耐药率为35%。
很大一部分患疟疾的孕妇对氯喹治疗无反应，需要使用替代药物。
