Hung K Y, Chen W Y, Yen T S, Yang C S, Ferng S H, Kao C L
Department of Internal Medicine, National Taiwan University Hospital, Taipei, R.O.C.
J Infect. 1996 May;32(3):227-30. doi: 10.1016/s0163-4453(96)80024-7.
Serum samples obtained from 69 histopathologically proven IgA nephropathy (IgAN) patients and 563 healthy controls were examined to evaluate the association between IgAN and common viral infections. Antibody titres to cytomegalovirus (CMV), herpes simplex virus (HSV), Vericella-Zoster virus (VZV), Influenza A (Inf. A) and Influenza B (Inf. B) viruses were determined, using a complement fixation test. The viral antibody titres were considered to be positive with dilutions of 1:8 or greater except for Epstein-Barr virus (EBV), studied using immunofluorescence, which was considered to be positive with dilutions of 1:10 or greater. The positive rate of Inf. B antibody in IgAN patients was significantly lower than that in controls. The frequency of positive CMV antibody titres was higher than for controls, but with only borderline statistical significance (P = 0.059). The frequency of positive CMV and Inf. B titres was compared by age in IgAN patients and controls. but showed no statistically significant difference. Comparisons of percentage distributions at each antibody dilution level to the common virus of IgAN patients and controls, but showed no statistically significant difference. Comparisons of percentage distributions at each antibody dilution level to the common virus of IgAN patients and controls were made; however, none showed a statistically significant difference. In conclusion, no absolutely higher frequency of positive antibody titres for common viruses was demonstrated in IgAN patients in this study.
对69例经组织病理学证实的IgA肾病（IgAN）患者和563例健康对照者采集的血清样本进行检测，以评估IgAN与常见病毒感染之间的关联。采用补体结合试验测定巨细胞病毒（CMV）、单纯疱疹病毒（HSV）、水痘 - 带状疱疹病毒（VZV）、甲型流感病毒（Inf. A）和乙型流感病毒（Inf. B）的抗体滴度。除采用免疫荧光法检测的EB病毒（EBV）外，病毒抗体滴度在1:8或更高稀释度时被认为呈阳性，EBV在1:10或更高稀释度时被认为呈阳性。IgAN患者中Inf. B抗体的阳性率显著低于对照组。CMV抗体滴度阳性的频率高于对照组，但仅具有边缘统计学意义（P = 0.059）。比较了IgAN患者和对照组中CMV和Inf. B滴度阳性频率按年龄的分布情况，但未显示出统计学显著差异。比较了IgAN患者和对照组在每种抗体稀释水平下针对常见病毒的百分比分布情况，但均未显示出统计学显著差异。总之，在本研究中，IgAN患者未表现出常见病毒抗体滴度阳性频率绝对更高的情况。
