对小鼠乳腺肿瘤病毒的免疫反应。
Immune response to mouse mammary tumour virus.
作者信息
Luther S A, Acha-Orbea H
机构信息
Ludwig Institute of Cancer Research, Lausanne Branch, University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.
出版信息
Curr Opin Immunol. 1996 Aug;8(4):498-502. doi: 10.1016/s0952-7915(96)80037-9.
PMID:8794013
Abstract
Superantigens of mouse mammary tumor virus induce a strong cognate interaction between T cells and B cells. In addition to amplifying the virus-infected B-cell pool, this superantigen-driven interaction leads to the differentiation of virus-specific B cells into plasma cells. Successful interaction between T cells and B cells is required for completion of the viral life cycle.
摘要
小鼠乳腺肿瘤病毒的超抗原可诱导T细胞与B细胞之间产生强烈的同源相互作用。除了扩增病毒感染的B细胞库外，这种由超抗原驱动的相互作用还会导致病毒特异性B细胞分化为浆细胞。病毒生命周期的完成需要T细胞与B细胞之间成功的相互作用。
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