Porcelli S A, Morita C T, Modlin R L
Division of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Curr Opin Immunol. 1996 Aug;8(4):510-6. doi: 10.1016/s0952-7915(96)80039-2.
Studies of two distinct human T-cell systems have provided the exciting finding that T cells are able to recognize non-peptide antigens: gammadelta T cells have been shown to recognize isopentenyl pyrophosphate and related structures and human CD1 has been shown to present microbial lipids and lipoglycans such as mycolic acids and lipoarabinomannan to T cells. T-cell responses to these non-peptide antigens should provide a strategic target for immunologic intervention in infectious disease.
对两种不同人类T细胞系统的研究带来了令人兴奋的发现：T细胞能够识别非肽抗原。已证明γδ T细胞能识别异戊烯基焦磷酸及相关结构，且已证明人类CD1能将微生物脂质和脂多糖（如分枝菌酸和脂阿拉伯甘露聚糖）呈递给T细胞。T细胞对这些非肽抗原的反应应为传染病免疫干预提供一个战略靶点。
