Temple S, Qian X
Department of Pharmacology and Neuroscience, Albany Medical College, New York 12208, USA.
Curr Opin Neurobiol. 1996 Feb;6(1):11-7. doi: 10.1016/s0959-4388(96)80003-1.
Several advances have been made recently in characterizing neural progenitor cells. In vertebrates, multipotential stem cells have been demonstrated in the developing forebrain both in vitro and in vivo, and a class of stem cells has been identified in the adult CNS. Factors that regulate the proliferation and differentiation of subtypes of neural progenitor cells have also been described. In invertebrates, progress has been made in identifying genes involved in neural progenitor cell specification, cell-fate choices and regulation.
最近在神经祖细胞的特性研究方面取得了一些进展。在脊椎动物中，已在发育中的前脑体外和体内证实了多能干细胞，并且在成体中枢神经系统中鉴定出了一类干细胞。还描述了调节神经祖细胞亚型增殖和分化的因子。在无脊椎动物中，在鉴定参与神经祖细胞特化、细胞命运选择和调节的基因方面取得了进展。
