Macdonald R, Wilson S W
Developmental Biology Research Centre, Kings College London, UK.
Curr Opin Neurobiol. 1996 Feb;6(1):49-56. doi: 10.1016/s0959-4388(96)80008-0.
Homologous members of the Pax gene family are required for eye development in Drosophila and vertebrates. Despite superficial similarities in the phenotypes of vertebrates with mutations in pax-6 and Drosophila eyeless mutants, it remains uncertain whether the two proteins encoded by these genes have comparable functions. The genetic cascade triggered by eyeless leads to eye formation, whereas pax-6 is not necessary for optic vesicle formation, but is required at other stages of eye development. A second vertebrate Pax gene, pax-2, is also required during eye development and appears to play a role during closure of the choroid fissure.
Pax基因家族的同源成员是果蝇和脊椎动物眼睛发育所必需的。尽管脊椎动物中pax - 6基因突变的表型与果蝇无眼突变体的表型有表面上的相似性，但这些基因编码的两种蛋白质是否具有可比功能仍不确定。由无眼基因触发的遗传级联反应导致眼睛形成，而pax - 6对于视泡形成不是必需的，但在眼睛发育的其他阶段是必需的。第二个脊椎动物Pax基因pax - 2在眼睛发育过程中也是必需的，并且似乎在脉络膜裂闭合过程中起作用。
