Culotti J G, Kolodkin A L
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Curr Opin Neurobiol. 1996 Feb;6(1):81-8. doi: 10.1016/s0959-4388(96)80012-2.
Neuronal growth cones respond to both contact-mediated and chemotropic guidance cues; these cues can be either attractive or repulsive. This past year has seen further characterization of two gene families implicated in long-range chemoattraction and chemorepulsion: the netrins and the semaphorins. Analysis of invertebrate members of these gene families demonstrates in vivo how netrins play multiple roles in axonal guidance in Caenorhabditis elegans, how specific domains of the netrin molecule confer attractive and repulsive guidance cues, and how semaphorins can function to generate neuromuscular specificity.
神经元生长锥对接触介导和化学趋向性引导线索均有反应；这些线索可以是吸引性的或排斥性的。过去一年里，对涉及长距离化学吸引和化学排斥的两个基因家族有了进一步的特性描述：即网蛋白和信号素。对这些基因家族无脊椎动物成员的分析表明，在秀丽隐杆线虫体内，网蛋白如何在轴突导向中发挥多种作用，网蛋白分子的特定结构域如何赋予吸引和排斥引导线索，以及信号素如何发挥作用以产生神经肌肉特异性。
