Denk W, Yuste R, Svoboda K, Tank D W
Bell Laboratories, Lucent Technologies, 700 Mountain Avenue, Murray Hill, New Jersey 07974, USA.
Curr Opin Neurobiol. 1996 Jun;6(3):372-8. doi: 10.1016/s0959-4388(96)80122-x.
Recent advances in optical imaging technology have enabled the measurement of Ca2+ dynamics in individual synaptic spines with high time resolution. Results from work using this new technology have confirmed the view that individual synaptic spines can act as functional chemical compartments with independent dynamics of second-messenger concentration. In particular, the ability of Ca2+ to directly mediate Hebbian coincidence detection has been confirmed.
光学成像技术的最新进展使得能够以高时间分辨率测量单个突触棘中的Ca2+动力学。使用这项新技术的研究结果证实了这样一种观点，即单个突触棘可以作为具有第二信使浓度独立动力学的功能性化学隔室。特别是，Ca2+直接介导赫布式巧合检测的能力已得到证实。
