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神经科学中功能性光学显微镜的数据处理综述。

Review of data processing of functional optical microscopy for neuroscience.

作者信息

Benisty Hadas, Song Alexander, Mishne Gal, Charles Adam S

机构信息

Yale Neuroscience, New Haven, Connecticut, United States.

Max Planck Institute for Intelligent Systems, Stuttgart, Germany.

出版信息

Neurophotonics. 2022 Oct;9(4):041402. doi: 10.1117/1.NPh.9.4.041402. Epub 2022 Aug 4.

DOI:10.1117/1.NPh.9.4.041402
PMID:35937186
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9351186/
Abstract

Functional optical imaging in neuroscience is rapidly growing with the development of optical systems and fluorescence indicators. To realize the potential of these massive spatiotemporal datasets for relating neuronal activity to behavior and stimuli and uncovering local circuits in the brain, accurate automated processing is increasingly essential. We cover recent computational developments in the full data processing pipeline of functional optical microscopy for neuroscience data and discuss ongoing and emerging challenges.

摘要

随着光学系统和荧光指示剂的发展,神经科学中的功能光学成像正在迅速发展。为了实现这些海量时空数据集在将神经元活动与行为和刺激相关联以及揭示大脑局部回路方面的潜力,精确的自动化处理变得越来越重要。我们涵盖了神经科学数据功能光学显微镜全数据处理流程中最近的计算进展,并讨论了当前和新出现的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eab/9351186/3f812c1d2a18/NPh-009-041402-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eab/9351186/d3f32af05c28/NPh-009-041402-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eab/9351186/9b52ccd66d2c/NPh-009-041402-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eab/9351186/cc36073d11e1/NPh-009-041402-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eab/9351186/6ce9dbd2f4d2/NPh-009-041402-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eab/9351186/3f812c1d2a18/NPh-009-041402-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eab/9351186/d3f32af05c28/NPh-009-041402-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eab/9351186/9b52ccd66d2c/NPh-009-041402-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eab/9351186/cc36073d11e1/NPh-009-041402-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eab/9351186/6ce9dbd2f4d2/NPh-009-041402-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1eab/9351186/3f812c1d2a18/NPh-009-041402-g005.jpg

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2
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Nat Neurosci. 2024 Jan;27(1):148-158. doi: 10.1038/s41593-023-01498-y. Epub 2023 Nov 30.
3
FIOLA: an accelerated pipeline for fluorescence imaging online analysis.
PLoS Comput Biol. 2023 Nov 30;19(11):e1011667. doi: 10.1371/journal.pcbi.1011667. eCollection 2023 Nov.
4
Special Section Guest Editorial: Computational Approaches for Neuroimaging.特刊客座编辑:神经影像学的计算方法
Neurophotonics. 2022 Oct;9(4):041401. doi: 10.1117/1.NPh.9.4.041401. Epub 2022 Sep 2.
5
GraFT: Graph Filtered Temporal Dictionary Learning for Functional Neural Imaging.GraFT:用于功能神经成像的图过滤时频字典学习。
IEEE Trans Image Process. 2022;31:3509-3524. doi: 10.1109/TIP.2022.3171414. Epub 2022 May 18.
FIOLA:荧光成像在线分析的加速流水线。
Nat Methods. 2023 Sep;20(9):1417-1425. doi: 10.1038/s41592-023-01964-2. Epub 2023 Sep 7.
4
Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission.具有改进的激活动力学和定位的谷氨酸指示剂,用于成像突触传递。
Nat Methods. 2023 Jun;20(6):925-934. doi: 10.1038/s41592-023-01863-6. Epub 2023 May 4.
5
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Nat Neurosci. 2022 Dec;25(12):1706-1713. doi: 10.1038/s41593-022-01202-6. Epub 2022 Nov 28.
6
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7
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8
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9
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Nat Methods. 2022 Apr;19(4):470-478. doi: 10.1038/s41592-022-01422-5. Epub 2022 Mar 28.
10
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Nat Commun. 2021 Nov 4;12(1):6391. doi: 10.1038/s41467-021-26730-w.