Berninger B, Poo M m
Department of Neurochemistry, Max Planck Institute for Psychiatry, Am Klopferspitz 18a, D-82152 Martinsried, Germany.
Curr Opin Neurobiol. 1996 Jun;6(3):324-30. doi: 10.1016/s0959-4388(96)80115-2.
A diversity of neurotrophic factors are required for the differentiation and survival of neurons and for maintaining their phenotype. By virtue of the rapid time scale of signal transduction in the cytosol, many of these factors also acutely regulate neuronal functions as diverse as synaptic transmission and nerve growth. These fast actions greatly expand the regulatory role of neurotrophic factors, particularly in the synaptic plasticity of developing nervous systems.
神经元的分化、存活以及维持其表型需要多种神经营养因子。由于胞质溶胶中信号转导的时间尺度很快，这些因子中的许多还能急性调节多种神经元功能，如突触传递和神经生长。这些快速作用极大地扩展了神经营养因子的调节作用，尤其是在发育中的神经系统的突触可塑性方面。
