Molday R S
Department of Biochemistry and Molecular Biology, 2146 Health Sciences Mall, University of British Columbia, Vancouver, V6T 1Z3, Canada.
Curr Opin Neurobiol. 1996 Aug;6(4):445-52. doi: 10.1016/s0959-4388(96)80048-1.
Cyclic-nucleotide-gated (CNG) channels play key roles in photoreceptor and olfactory signal-transduction pathways. Recent studies have focused on the molecular characterization of CNG channel subunits and on the identification of the structural domains that contribute to ligand selectivity and affinity, ion gating and permeation, and regulation of channel activity. Calmodulin has been shown to bind directly to the rod and olfactory channels and to modulate their sensitivity to cyclic nucleotides. This Ca2+-dependent regulation of channel activity appears to play a role in the termination of the signal-transduction pathway in olfactory neurons and rod photoreceptor cells. It remains to be determined whether calmodulin also regulates the activity of related channels in other cells.
环核苷酸门控（CNG）通道在光感受器和嗅觉信号转导途径中起关键作用。最近的研究集中在CNG通道亚基的分子特征以及对配体选择性和亲和力、离子门控和通透以及通道活性调节有贡献的结构域的鉴定上。已证明钙调蛋白直接与视杆和嗅觉通道结合，并调节它们对环核苷酸的敏感性。这种通道活性的Ca2+依赖性调节似乎在嗅觉神经元和视杆光感受器细胞的信号转导途径终止中起作用。钙调蛋白是否也调节其他细胞中相关通道的活性仍有待确定。
