Parsons P A
Division of Science and Technology, Griffith University, Nathan, Brisbane, Qld, Australia.
Mech Ageing Dev. 1996 Jun 25;87(3):211-8. doi: 10.1016/0047-6374(96)01710-1.
Survival to old age is enhanced by high vitality and resilience associated with substantial physiological and morphological homeostasis. This is underlain by genes for stress resistance, which confer high metabolic efficiency and hence adaptation to the energy costs of the stresses to which free-living populations are exposed. Under the stress theory of ageing, selection for genes for stress resistance is primary, and achieved life-span is secondary. In some human populations of the modern era, selection for stress resistance is less intense than in earlier times, because of adequate nutrition and reduced exposure to environmental stresses. Such relaxed selection should permit the accumulation of deleterious mutants that are likely to be stress sensitive. Accordingly, increased maximum life-span in future human populations would appear difficult to achieve.
高活力和恢复力与大量生理和形态稳态相关，这有助于活到老年。其基础是抗应激基因，这些基因赋予高代谢效率，从而适应自由生活群体所面临的应激能量成本。根据衰老的应激理论，对抗应激基因的选择是首要的，而达到的寿命是次要的。在现代的一些人群中，由于营养充足和接触环境应激减少，对抗应激的选择不如早期强烈。这种宽松的选择应该会允许可能对压力敏感的有害突变体积累。因此，未来人类群体中最大寿命的增加似乎难以实现。
