Dalecki D, Raeman C H, Child S Z, Carstensen E L
Department of Electrical Engineering, University of Rochester, NY 14627, USA.
Ultrasound Med Biol. 1996;22(4):493-6. doi: 10.1016/0301-5629(96)00033-6.
This study tested the hypothesis that intestinal hemorrhage produced by exposure to lithotripter fields depends upon the presence of gas in the intestine. The extent of hemorrhage in the gas-containing intestines of pregnant mice was compared to the amount of hemorrhage in the bubble-free intestines of their fetuses. On day 18 of gestation, the abdominal regions of pregnant C3H mice (n = 6) were exposed to 200 pulses from a piezoelectric lithotripter. Acoustic pulses had a peak pressure amplitude of 10 MPa and were administered at a rate of approximately 1 Hz. All maternal intestines showed hemorrhagic regions extending several centimeters in length. In contrast, only 1 of 43 exposed fetuses showed an intestinal hemorrhage and this one lesion was less than 1 mm in diameter. These results support the hypothesis of the study and are consistent with a cavitation-related mechanism for the production of intestinal hemorrhage by exposure to acoustic fields.
暴露于碎石机场产生的肠道出血取决于肠道内气体的存在。将怀孕小鼠含气肠道的出血程度与其胎儿无气泡肠道的出血情况进行了比较。在妊娠第18天，对怀孕的C3H小鼠（n = 6）腹部区域施加来自压电碎石机的200个脉冲。声脉冲的峰值压力幅度为10 MPa，给药频率约为1 Hz。所有母体肠道均显示出长度达数厘米的出血区域。相比之下，43只暴露的胎儿中只有1只出现肠道出血，且该病变直径小于1毫米。这些结果支持了该研究的假设，并与暴露于声场导致肠道出血的空化相关机制相一致。
