Rodwell R L, Gray P H, Taylor K M, Minchinton R
Division of Haematology, Mater Misericordiae Hospitals, South Brisbane 4101, Australia.
Arch Dis Child Fetal Neonatal Ed. 1996 Jul;75(1):F57-8. doi: 10.1136/fn.75.1.f57.
Granulocyte colony stimulating factor (G-CSF) treatment was successfully used in three preterm infants with alloimmune neonatal neutropenia (AINN). Two infants had persistent neutropenia despite treatment with intravenous immunoglobulin and random donor granulocyte transfusions for presumed sepsis. Neutrophil counts returned to normal with G-CSF treatment; the response was least convincing in one infant with fulminant necrotising enterocolits. It is suggested that treatment with G-CSF be considered early for the treatment of infants with AINN.
粒细胞集落刺激因子（G-CSF）治疗成功应用于3例患有同种免疫性新生儿中性粒细胞减少症（AINN）的早产儿。尽管对2例疑似败血症的婴儿进行了静脉注射免疫球蛋白和随机供体粒细胞输血治疗，但仍持续存在中性粒细胞减少症。经G-CSF治疗后，中性粒细胞计数恢复正常；在1例患有暴发性坏死性小肠结肠炎的婴儿中，反应最不明显。建议早期考虑用G-CSF治疗AINN婴儿。
