Felix J K, Calhoun D A
Pediatrix Medical Group, Inc., Arnot Ogden Medical Center, Elmira, NY 14905, USA.
Pediatrics. 2000 Aug;106(2 Pt 1):340-2. doi: 10.1542/peds.106.2.340.
Alloimmune neonatal neutropenia (ANN) is an uncommon but potentially life-threatening disorder of the neonate and young infant. Hematologically, the mother's peripheral neutrophil count is normal. However, the passive transfer of maternal immunoglobulin G neutrophil-specific antibodies and the subsequent sensitization of fetal neutrophils can result in severe neutropenia in the neonate. Generally, ANN is a self-limiting condition, but with severe bacterial infection, mortality can be high. We present the clinical features of monozygous twins delivered at 33 weeks' postconception with this condition. This case report is unique in that it occurred in twins born prematurely and was attributable to antibodies against 2 neutrophil-specific antigens, NA1 and NB1. A brief review of the diagnosis, management, and treatment of ANN is presented.
同种免疫性新生儿中性粒细胞减少症（ANN）是一种新生儿和幼儿中罕见但可能危及生命的疾病。血液学上，母亲的外周中性粒细胞计数正常。然而，母体免疫球蛋白G中性粒细胞特异性抗体的被动转移以及随后胎儿中性粒细胞的致敏可导致新生儿严重中性粒细胞减少。一般来说，ANN是一种自限性疾病，但在发生严重细菌感染时，死亡率可能很高。我们介绍了在孕33周出生的单卵双胞胎患此病的临床特征。本病例报告的独特之处在于它发生在早产双胞胎中，且归因于针对两种中性粒细胞特异性抗原NA1和NB1的抗体。本文还简要回顾了ANN的诊断、管理和治疗。
