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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Keratinocyte Laboratory, Imperial Cancer Research Fund, London, U.K.

Clin Sci (Lond). 1996 Aug;91(2):141-6. doi: 10.1042/cs0910141.

The keratinocytes in human epidermis are constantly turned over and replaced by a population of stem cells located in the basal epidermal layer. Until recently there were no markers allowing the isolation of viable epidermal stem cells. However, it has now been shown that epidermal stem cells can be isolated both in vitro and direct from the epidermis as they express high levels of functional beta 1 integrin family receptors for extracellular matrix proteins. 2. The evidence for integrins as stem cell markers and the insights that have been gained into stem cell behaviour are reviewed.

人类表皮中的角质形成细胞不断更新，并被位于表皮基底层的一群干细胞所取代。直到最近，还没有能够分离出有活力的表皮干细胞的标志物。然而，现已表明，表皮干细胞可以在体外分离，也可以直接从表皮中分离，因为它们表达高水平的用于细胞外基质蛋白的功能性β1整合素家族受体。2. 本文综述了整合素作为干细胞标志物的证据以及在干细胞行为方面所获得的见解。

Keratinocyte Laboratory, Imperial Cancer Research Fund, London, U.K.

Clin Sci (Lond). 1996 Aug;91(2):141-6. doi: 10.1042/cs0910141.

The keratinocytes in human epidermis are constantly turned over and replaced by a population of stem cells located in the basal epidermal layer. Until recently there were no markers allowing the isolation of viable epidermal stem cells. However, it has now been shown that epidermal stem cells can be isolated both in vitro and direct from the epidermis as they express high levels of functional beta 1 integrin family receptors for extracellular matrix proteins. 2. The evidence for integrins as stem cell markers and the insights that have been gained into stem cell behaviour are reviewed.

人类表皮中的角质形成细胞不断更新，并被位于表皮基底层的一群干细胞所取代。直到最近，还没有能够分离出有活力的表皮干细胞的标志物。然而，现已表明，表皮干细胞可以在体外分离，也可以直接从表皮中分离，因为它们表达高水平的用于细胞外基质蛋白的功能性β1整合素家族受体。2. 本文综述了整合素作为干细胞标志物的证据以及在干细胞行为方面所获得的见解。