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本文引用的文献

1
Effects of sleep deprivation and sleep fragmentation on upper airway collapsibility in normal subjects.睡眠剥夺和睡眠片段化对正常受试者上气道可塌陷性的影响。
Am J Respir Crit Care Med. 1994 Aug;150(2):481-5. doi: 10.1164/ajrccm.150.2.8049833.
2
Sleep apnea syndromes: impact of sleep and sleep states.
Sleep. 1980;3(3-4):227-34. doi: 10.1093/sleep/3.3-4.227.
3
Endorphins and the control of breathing. Ability of naloxone to restore flow-resistive load compensation in chronic obstructive pulmonary disease.内啡肽与呼吸控制。纳洛酮恢复慢性阻塞性肺疾病中气流阻力负荷代偿的能力。
N Engl J Med. 1981 May 14;304(20):1190-5. doi: 10.1056/NEJM198105143042002.
4
Simultaneous circadian variations of plasma ACTH, beta-lipotropin, beta-endorphin and cortisol.血浆促肾上腺皮质激素、β-促脂素、β-内啡肽和皮质醇的同步昼夜变化。
Horm Res. 1983;17(3):147-52. doi: 10.1159/000179690.
5
Induction of upper airway occlusion in sleeping individuals with subatmospheric nasal pressure.在睡眠个体中，通过低于大气压的鼻腔压力诱导上气道阻塞。
J Appl Physiol (1985). 1988 Feb;64(2):535-42. doi: 10.1152/jappl.1988.64.2.535.
6
Naloxone improves sleep apnea in obese humans.纳洛酮可改善肥胖人群的睡眠呼吸暂停。
Int J Obes. 1985;9(4):233-9.
7
Naloxone alters the early response to an inspiratory flow-resistive load.纳洛酮会改变对吸气性气流阻力负荷的早期反应。
J Appl Physiol (1985). 1989 Nov;67(5):1747-53. doi: 10.1152/jappl.1989.67.5.1747.
8
Endogenous opiates modulate the postapnea ventilatory response in the obstructive sleep apnea syndrome.内源性阿片类物质调节阻塞性睡眠呼吸暂停综合征中的呼吸暂停后通气反应。
Am Rev Respir Dis. 1991 Jun;143(6):1282-7. doi: 10.1164/ajrccm/143.6.1282.

纳洛酮对正常睡眠受试者上气道可塌陷性的影响。

Effects of naloxone on upper airway collapsibility in normal sleeping subjects.

作者信息

Meurice J C, Marc I, Sériès F

机构信息

Unité de Recherche, Centre de Pneumologie, Hôpital Laval, Université Laval, Sainte-Foy, Québec, Canada.

出版信息

Thorax. 1996 Aug;51(8):851-2. doi: 10.1136/thx.51.8.851.

DOI:10.1136/thx.51.8.851
PMID:8795677
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC472571/
Abstract

BACKGROUND

To evaluate the possible influence of endorphin release on upper airway collapsibility the effects of naloxone, an opiate receptor antagonist, were measured.

METHODS

The effects of naloxone on upper airway collapsibility were studied in five normal sleeping men in a pilot study. During a sleep fragmentation night the subjects received either naloxone or a volume matched saline placebo in a double blind crossover design. Critical pressure (Pcrit) was measured during a morning nap following sleep fragmentation.

RESULTS

The plasma levels of endorphins increased during sleep fragmentation nights. Pcrit was significantly greater after placebo than after naloxone infusion.

CONCLUSIONS

Naloxone may reduce upper airway collapsibility in normal sleeping subjects following sleep fragmentation.

摘要

背景

为评估内啡肽释放对上气道可塌陷性的可能影响，测定了阿片受体拮抗剂纳洛酮的作用。

方法

在一项初步研究中，对五名正常睡眠男性进行了纳洛酮对上气道可塌陷性影响的研究。在睡眠片段化的夜晚，受试者在双盲交叉设计中接受纳洛酮或等体积生理盐水安慰剂。在睡眠片段化后的上午小睡期间测量临界压力（Pcrit）。

结果

睡眠片段化夜晚期间内啡肽的血浆水平升高。安慰剂后Pcrit显著高于纳洛酮输注后。

结论

纳洛酮可能会降低正常睡眠受试者在睡眠片段化后的上气道可塌陷性。