纳洛酮对正常睡眠受试者上气道可塌陷性的影响。
Effects of naloxone on upper airway collapsibility in normal sleeping subjects.
作者信息
Meurice J C, Marc I, Sériès F
机构信息
Unité de Recherche, Centre de Pneumologie, Hôpital Laval, Université Laval, Sainte-Foy, Québec, Canada.
出版信息
Thorax. 1996 Aug;51(8):851-2. doi: 10.1136/thx.51.8.851.
BACKGROUND
To evaluate the possible influence of endorphin release on upper airway collapsibility the effects of naloxone, an opiate receptor antagonist, were measured.
METHODS
The effects of naloxone on upper airway collapsibility were studied in five normal sleeping men in a pilot study. During a sleep fragmentation night the subjects received either naloxone or a volume matched saline placebo in a double blind crossover design. Critical pressure (Pcrit) was measured during a morning nap following sleep fragmentation.
RESULTS
The plasma levels of endorphins increased during sleep fragmentation nights. Pcrit was significantly greater after placebo than after naloxone infusion.
CONCLUSIONS
Naloxone may reduce upper airway collapsibility in normal sleeping subjects following sleep fragmentation.
背景
为评估内啡肽释放对上气道可塌陷性的可能影响，测定了阿片受体拮抗剂纳洛酮的作用。
方法
在一项初步研究中，对五名正常睡眠男性进行了纳洛酮对上气道可塌陷性影响的研究。在睡眠片段化的夜晚，受试者在双盲交叉设计中接受纳洛酮或等体积生理盐水安慰剂。在睡眠片段化后的上午小睡期间测量临界压力（Pcrit）。
结果
睡眠片段化夜晚期间内啡肽的血浆水平升高。安慰剂后Pcrit显著高于纳洛酮输注后。
结论
纳洛酮可能会降低正常睡眠受试者在睡眠片段化后的上气道可塌陷性。
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