Drew M, Barker H F, Ball J, Pearson C, Cook G, Franklin I
Department of Immunology, Medical School, Birmingham, U.K.
Leuk Res. 1996 Jul;20(7):619-24. doi: 10.1016/0145-2126(95)00097-6.
The biology of normal plasma cells and the pathophysiology of human multiple myeloma remain poorly understood. Functional assays are scarce and at present cell phenotyping is providing the most information about how human plasma cells may behave. Three different types of human plasma cells: normal, fresh neoplastic myeloma cells and plasma cell lines, have been studied for their reactivity with antibodies to the beta-1 integrins (Very Late Antigens; VLAs), including a panel obtained from the Vth International Workshop on Leucocyte Differentiation Antigens. Most plasma cell targets express VLA-4 (CD49d positive) and the common beta chain recognized by CD29. CD49e (VLA-5) was occasionally positive. Other VLAs were not usually expressed. These data suggest the wide use by plasma cells of VLA-4, possibly as a ligand with fibronectin and high endothelial venules (HEV). Of other adhesion structures expressed by plasma cells, only CD44 is seen as frequently, and this is also a HEV ligand.
正常浆细胞的生物学特性以及人类多发性骨髓瘤的病理生理学仍未被充分了解。功能检测方法稀缺，目前细胞表型分析提供了关于人类浆细胞可能行为的最多信息。研究了三种不同类型的人类浆细胞：正常浆细胞、新鲜的肿瘤性骨髓瘤细胞和浆细胞系，检测它们与β-1整合素（极晚期抗原；VLA）抗体的反应性，其中包括从第五届白细胞分化抗原国际研讨会获得的一组抗体。大多数浆细胞靶点表达VLA-4（CD49d阳性）以及可被CD29识别的共同β链。CD49e（VLA-5）偶尔呈阳性。其他VLA通常不表达。这些数据表明浆细胞广泛使用VLA-4，可能作为与纤连蛋白和高内皮微静脉（HEV）的配体。在浆细胞表达的其他黏附结构中，只有CD44同样常见，并且它也是一种HEV配体。
