Kaler L W, Haensly W E
Am J Vet Res. 1977 Jun;38(6):897-901.
Neutral lipid and adenyl cyclase were evaluated to determine their concentrations in the kidney of the aging cat. Kidneys from 24 domestic cats 2 months to 7.5 years old in 6 age groups were examined by light microscopic and histochemical methods. Activity in anatomic components of the kidney was assessed on a quantitative basis for evaluation of mean activity between the age groups. Renal components generally were stable in activity in the cats with advancing age. A significant increase in lipid concentration occurred in the convoluted segments of the proximal tubules with advancing age. In contrast, the straight segments of the proximal tubules displayed a significant decrease in lipid concentration with aging. Significant increases in adenyl cyclase activity were evident with aging in the ascending thick limb of Henle's loop and distal tubules.
对中性脂质和腺苷酸环化酶进行评估，以确定它们在老龄猫肾脏中的浓度。采用光学显微镜和组织化学方法，对6个年龄组中24只2个月至7.5岁的家猫肾脏进行了检查。对肾脏各解剖成分的活性进行定量评估，以评价不同年龄组之间的平均活性。随着年龄增长，猫肾脏各成分的活性总体上保持稳定。随着年龄增长，近端小管曲段的脂质浓度显著增加。相反，近端小管直段的脂质浓度随衰老而显著降低。随着年龄增长，亨利袢升支粗段和远端小管的腺苷酸环化酶活性明显增加。
