Kaler L W, Haensly W E
Am J Vet Res. 1978 Aug;39(8):1331-6.
Hexokinase, aldolase, L-alpha-glycerophosphate dehydrogenase, and lactate dehydrogenase activities were determined in the kidney of the aging cat. Kidneys from 24 domestic cats 2 months to 7.5 years old in 6 age groups were examined by light microscopic and histochemical methods. Enzyme activities in anatomic components of the kidney were assessed on a quantitative basis for evaluation of mean activity between the age groups. In the cats with advancing age, renal components generally had stable activity. A significant (P less than 0.05) increase in hexokinase activity occurred with advancing age in the ascending part of the renal loop (Henle's loop) and in the distal convoluted tubule. Significant (P less than 0.05) increases in aldolase activity with aging were in cortical connective tissue, internal part of the glomerular capsule (podocytes), distal convoluted tubule, and convoluted segment (Pi) of the proximal portion of the nephron tubule. L-alpha-glycerophosphate dehydrogenase and lactate dehydrogenase activity increased significantly with aging in the convoluted (Pi) segment of the proximal portion of the nephron tubule.
测定了老龄猫肾脏中己糖激酶、醛缩酶、L-α-甘油磷酸脱氢酶和乳酸脱氢酶的活性。采用光学显微镜和组织化学方法，对6个年龄组的24只2月龄至7.5岁的家猫肾脏进行了检查。对肾脏各解剖成分中的酶活性进行了定量评估，以评价各年龄组之间的平均活性。随着猫年龄的增长，肾脏各成分的活性总体上保持稳定。在肾袢升支（亨氏袢）和远曲小管中，己糖激酶活性随年龄增长显著（P<0.05）升高。随着年龄增长，醛缩酶活性显著（P<0.05）升高的部位有皮质结缔组织、肾小球囊内部（足细胞）、远曲小管和近端肾小管近曲段（Pi）。近端肾小管近曲段（Pi）中，L-α-甘油磷酸脱氢酶和乳酸脱氢酶活性随年龄增长显著升高。
