Rodgers D, Khoo K, MacEachen M, Oven M, Beatty W W
University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Altern Ther Health Med. 1996 Sep;2(5):70-4.
Drug treatments for multiple sclerosis are expensive, may cause side effects, and do not have demonstrated efficacy for cognitive deficits associated with this disease.
To test the effectiveness of a multimodal cognitive therapy on cognitive and physical measures known to be affected in multiple sclerosis.
Quasi-experimental wait-list control.
Alternative medicine clinic.
27 persons with clinically definite multiple sclerosis.
Multimodal cognitive therapy.
Neuropsychological measures of verbal learning and memory, abstraction, vocabulary, and information processing speed; Beck Depression Inventory; tactile sensitivity of the hands; grip strength; and visual acuity.
12 of 14 patients in the therapy group and 10 of 13 patients in the control group completed 24 weeks of treatment and all assessments. Patients who received therapy showed significantly greater improvement in verbal learning, verbal abstraction, depression, and some measures of grip strength and tactile sensitivity than did patients in the untreated control group. The groups did not differ in the magnitude of change on vocabulary, information processing speed, or visual acuity.
Cognitive therapy appears to be a promising treatment for ameliorating some symptoms of multiple sclerosis. A larger study with a randomized design and additional outcome measures is warranted.
多发性硬化症的药物治疗费用高昂，可能会引起副作用，并且对于与该疾病相关的认知缺陷尚未显示出疗效。
测试多模式认知疗法对已知受多发性硬化症影响的认知和身体指标的有效性。
准实验性等待列表对照。
替代医学诊所。
27例临床确诊的多发性硬化症患者。
多模式认知疗法。
言语学习与记忆、抽象思维、词汇量和信息处理速度的神经心理学指标；贝克抑郁量表；手部触觉敏感性；握力；以及视力。
治疗组的14例患者中有12例、对照组的13例患者中有10例完成了24周的治疗及所有评估。接受治疗的患者在言语学习、言语抽象思维、抑郁以及一些握力和触觉敏感性指标方面的改善明显大于未治疗的对照组患者。两组在词汇量、信息处理速度或视力的变化幅度上没有差异。
认知疗法似乎是改善多发性硬化症某些症状的一种有前景的治疗方法。有必要进行一项采用随机设计并增加结局指标的更大规模研究。
