吸烟与性别对茶碱代谢的影响。

The influence of cigarette smoking and sex on theophylline disposition.

作者信息

Powell J R, Thiercelin J F, Vozeh S, Sansom L, Riegelman S

出版信息

Am Rev Respir Dis. 1977 Jul;116(1):17-23. doi: 10.1164/arrd.1977.116.1.17.

DOI:10.1164/arrd.1977.116.1.17

Abstract

The effects of cigarette smoking and sex on theophylline clearance, elimination rate constant, and apparent volume of distribution were examined in 28 healthy, young adults given single oral doses of theophylline or aminophylline. Two-way analysis of variance showed no sex effect but a significant effect of smoking habit on theophylline clearance and elimination rate constant. Neither sex nor smoking had an effect on the apparent volume of distribution. The respective mean clearance, elimination rate constant, and volume of distribution were, in nonsmokers, 0.040 +/- 0.008 (SD) liter per hour per kg, 0.084 +/- 0.015 hr-1, 0.47 +/- 0.08 liter per kg; heavy smokers, 0.063 +/- 0.019 liter per hour per kg, 0.129 +/- 0.045 hr-1, 0.50 +/- 0.06 liter per kg; and ex-smokers, 0.051 +/- 0.10 liter per hour per kg, 0.108 +/- 0.025 hr-1, 0.49 +/- 0.08 liter per kg. Cigarette smoking appeared to induce theophylline metabolism as reflected by the mean theophylline half-life in smokers (5.4 hours) versus nonsmokers (8.3 hours). The effect of cigarette smoking on theophylline clearance may be an important consideration in the clinical use of the drug.

摘要

在28名健康的年轻成年人单次口服茶碱或氨茶碱后，研究了吸烟和性别对茶碱清除率、消除速率常数及表观分布容积的影响。双向方差分析显示性别无影响，但吸烟习惯对茶碱清除率和消除速率常数有显著影响。性别和吸烟对表观分布容积均无影响。非吸烟者的平均清除率、消除速率常数和分布容积分别为每小时每千克0.040±0.008（标准差）升、0.084±0.015小时⁻¹、每千克0.47±0.08升；重度吸烟者分别为每小时每千克0.063±0.019升、0.129±0.045小时⁻¹、每千克0.50±0.06升；戒烟者分别为每小时每千克0.051±0.10升、0.108±0.025小时⁻¹、每千克0.49±0.08升。吸烟似乎诱导了茶碱代谢，吸烟者的平均茶碱半衰期（5.4小时）与非吸烟者（8.3小时）相比即可反映这一点。吸烟对茶碱清除率的影响在该药物的临床应用中可能是一个重要的考虑因素。