Smith T J, Peters J M, Reading J C, Castle C H
Am Rev Respir Dis. 1977 Jul;116(1):31-9. doi: 10.1164/arrd.1977.116.1.31.
The pulmonary function of 113 copper smelter workers was measured in 1973 and again in 1974 to asses the effects of chronic exposure to sulfur dioxide. Respiratory symptoms, smoking history, occupational history, and pulmonary function as measured by forced vital capacity and 1-sec forced expiratory volume were recorded. Exposures to sulfur dioxide, respirable particulates, sulfates, and copper were sampled at intervals throughout the year by personal monitoring. Exposure to 1.0 to 2.5 ppm of sulfur dioxide was associated with excessive loss of 1-sec forced expiratory volume during the year and an increase in respiratory symptoms, after controlling for smoking. No significant interaction between sulfur dioxide and concurrent exposure to respirable particulates on pulmonary function was found. Workers with 1-sec forced expiratory volume below normal on initial measurements (based on their age and height) showed evidence of even greater losses of pulmonary function related to sulfur dioxide exposure.
1973年对113名铜冶炼工人的肺功能进行了测量，并于1974年再次测量，以评估长期接触二氧化硫的影响。记录了呼吸症状、吸烟史、职业史以及通过用力肺活量和1秒用力呼气量测量的肺功能。通过个人监测全年定期采集二氧化硫、可吸入颗粒物、硫酸盐和铜的暴露样本。在控制吸烟因素后，接触1.0至2.5 ppm的二氧化硫与一年内1秒用力呼气量的过度损失以及呼吸症状的增加有关。未发现二氧化硫与同时接触可吸入颗粒物对肺功能有显著的相互作用。初始测量时1秒用力呼气量低于正常水平（根据其年龄和身高）的工人显示出与二氧化硫暴露相关的肺功能损失更大的证据。
