Abbasoglu O E, Sener E C, Sanac A S
Hacettepe University School of Medicine, Department of Ophthalmology, Sihhiye Ankara, Turkey.
Eye (Lond). 1996;10 ( Pt 3):385-91. doi: 10.1038/eye.1996.78.
Botulinum toxin type A (BTA) treatment is an alternative to strabismus surgery. In this retrospective study the data on 45 esotropic and 49 exotropic patients with concomitant strabismus who were treated with BTA were analysed for dose-effect relationship, the effect of repeat doses and amblyopia on success of botulinum treatment. The esotropic patients were treated with a total of 80 and exotropic patients with 91 injections. The deviations were corrected within 5 degrees of straight in 33% of esotropic and 18% of exotropic patients. In esotropic patients the effect was dose dependent. This relation was not shown in exotropic patients. The repeat doses of BTA corrected the deviation to the same extent as the primary ones for both esotropic and exotropic patients.
A型肉毒杆菌毒素（BTA）治疗是斜视手术的一种替代方法。在这项回顾性研究中，分析了45例内斜视和49例外斜视伴共同性斜视患者接受BTA治疗的数据，以探讨剂量效应关系、重复剂量的影响以及弱视对肉毒杆菌治疗成功率的影响。内斜视患者共接受了80次注射，外斜视患者接受了91次注射。33%的内斜视患者和18%的外斜视患者的斜视度在5度以内得到矫正。在内斜视患者中，效果呈剂量依赖性。外斜视患者未显示出这种关系。对于内斜视和外斜视患者，BTA的重复剂量与初次剂量矫正斜视的程度相同。
