Foley S, Blattel S A, Martin A G
Division of Dermatology, Washington University School of Medicine, St Louis, MO 63110, USA.
Am J Contact Dermat. 1996 Jun;7(2):104-8.
Squaric acid dibutylester (SADBE) is a potent topical sensitizer used in the treatment of various cutaneous conditions. Currently, there are no standardized protocols defining safe sensitization methods or treatment regimens following sensitization.
This is a literature review of the clinical use of SADBE and a report of our experience with SADBE therapy and its potential hazards.
SADBE was applied with a cotton swab to the forearm of 14 patients to induce contact dermatitis.
Ten of 14 patients (71%) had severe eczematous reactions at the site of sensitization, and 9 of 14 (64%) developed disseminated reactions.
Standard protocols delineating safe methods of sensitization and treatment with SADBE need further development.
二丁基 Squaric 酸酯（SADBE）是一种强效外用致敏剂，用于治疗各种皮肤疾病。目前，尚无标准化方案来定义安全的致敏方法或致敏后的治疗方案。
这是一篇关于 SADBE 临床应用的文献综述，并报告我们使用 SADBE 治疗的经验及其潜在危害。
用棉签将 SADBE 涂抹于 14 名患者的前臂以诱发接触性皮炎。
14 名患者中有 10 名（71%）在致敏部位出现严重湿疹样反应，14 名中有 9 名（64%）出现播散性反应。
需要进一步制定描述 SADBE 安全致敏方法和治疗方法的标准化方案。
