Watson W J, Atchison S R, Harlass F E
Department of Perinatal Medicine, Sioux Valley Hospital, Sioux Falls, South Dakota, USA.
J Matern Fetal Med. 1996 May-Jun;5(3):151-4. doi: 10.1002/(SICI)1520-6661(199605/06)5:3<151::AID-MFM10>3.0.CO;2-M.
Neuromuscular blocking agents, used to arrest fetal motion for invasive intrauterine procedures, may cause temporary fetal heart rate changes. After 21 invasive procedures using either pancuronium bromide or vecuronium bromide, post-procedure fetal heart rate tracings were retrospectively compared. Pancuronium was associated with an increased fetal heart rate and decreased beat-to-beat variability for 2.5 hours after its use, whereas vecuronium caused no fetal heart rate changes. Vecuronium bromide offers advantages over pancuronium, because the decreased effect on the fetal heart allows better assessment of fetal well-being immediately following invasive intrauterine procedures.
用于侵入性宫内操作中使胎儿活动停止的神经肌肉阻滞剂可能会导致胎儿心率暂时改变。在使用泮库溴铵或维库溴铵进行21次侵入性操作后，对术后胎儿心率描记图进行了回顾性比较。使用泮库溴铵后，胎儿心率增加且逐搏变异性降低，持续2.5小时，而维库溴铵未引起胎儿心率变化。维库溴铵比泮库溴铵具有优势，因为其对胎儿心脏的影响较小，使得在侵入性宫内操作后能更好地评估胎儿健康状况。
