Timor-Tritsch I E, Greenebaum E, Monteagudo A, Baxi L
Department of Obstetrics and Gynecology, Columbia Presbyterian Medical Center, New York, New York 10032, USA.
J Matern Fetal Med. 1996 Jul-Aug;5(4):182-5. doi: 10.1002/(SICI)1520-6661(199607/08)5:4<182::AID-MFM4>3.0.CO;2-G.
We present and discuss major current theories about the developmental natural history of the anencephalic human fetus. We confirm previous observations made using transvaginal ultrasonography of exencephalic fetuses which were later imaged and/or delivered as anencephalic fetuses. We explore the possibility of proving the theory of the slowly rubbed-off exposed brain tissue by cytologic examination and special staining of aspirated cells in amniotic fluid. Three fetuses with a typical sonographic picture of exencephaly at 13-15 postmenstrual weeks underwent amniocentesis. The aspirated fluid contained pathognomonic neural cells. The same fetuses later showed the characteristic sonographic and postabortion picture of anencephaly. Our results support the theory that exencephaly is the forerunner of anencephaly.
我们展示并讨论了当前关于无脑儿胎儿发育自然史的主要理论。我们证实了先前使用经阴道超声对无脑儿胎儿进行检查的观察结果，这些胎儿后来被成像和/或作为无脑儿分娩。我们探讨了通过对羊水抽吸细胞进行细胞学检查和特殊染色来证明缓慢擦除的暴露脑组织理论的可能性。三名在月经周期后13 - 15周具有典型无脑儿超声图像的胎儿接受了羊膜穿刺术。抽吸的液体中含有特征性神经细胞。同样的胎儿后来显示出无脑儿的特征性超声和流产后图像。我们的结果支持无脑儿是无脑畸形先兆的理论。
