Varner M W, Dildy G A, Hunter C, Dudley D J, Clark S L, Mitchell M D
Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, USA.
J Soc Gynecol Investig. 1996 Jan-Feb;3(1):17-9. doi: 10.1016/1071-5576(95)00044-5.
To determine the concentrations of epidermal growth factor (EGF) in amniotic fluid (AF) from women during late pregnancy, with and without pathophysiologic complications.
All AFs were collected by amniocentesis from the following groups: gestational age at least 38 weeks (n = 15); gestational age 36-37 weeks (n = 10); gestational age 35 weeks (n = 5); labor 34 weeks or less, delivered within 7 days (n = 10); labor 34 weeks or less, undelivered (n = 10); chorioamnionitis (n = 7); gestational age-matched controls (n = 7); term, in labor (n = 8); term, not in labor (n = 8); intrauterine growth restriction (IUGR) 38 weeks or more (n = 8); macrosomia at 38 weeks or more (n = 10). Epidermal growth factor was assayed using a specific radioimmunoassay.
Amniotic fluid EGF levels increase rapidly in late pregnancy but are not altered by chorioamnionitis or by term or preterm labor. Intrauterine growth restriction is associated with lower EGF levels in AF, but macrosomia is without effect.
Epidermal growth factor levels in AF are increased near term and decreased in pregnancies complicated by IUGR; they may be an indicator of specific maturational events.
测定晚期妊娠女性羊水（AF）中表皮生长因子（EGF）的浓度，包括有和无病理生理并发症的情况。
通过羊膜穿刺术收集以下各组的羊水：孕周至少38周（n = 15）；孕周36 - 37周（n = 10）；孕周35周（n = 5）；34周及以下早产且在7天内分娩（n = 10）；34周及以下早产且未分娩（n = 10）；绒毛膜羊膜炎（n = 7）；孕周匹配的对照组（n = 7）；足月临产（n = 8）；足月未临产（n = 8）；38周及以上胎儿宫内生长受限（IUGR）（n = 8）；38周及以上巨大儿（n = 10）。采用特异性放射免疫分析法测定表皮生长因子。
晚期妊娠时羊水EGF水平迅速升高，但不受绒毛膜羊膜炎、足月或早产影响。胎儿宫内生长受限与羊水中较低的EGF水平相关，但巨大儿对此无影响。
足月时羊水表皮生长因子水平升高，而在合并胎儿宫内生长受限的妊娠中降低；它们可能是特定成熟事件的一个指标。
