羊水：发育中肠道的营养因子来源。
Amniotic fluid: Source of trophic factors for the developing intestine.
作者信息
Dasgupta Soham, Arya Shreyas, Choudhary Sanjeev, Jain Sunil K
机构信息
Soham Dasgupta, Shreyas Arya, Sunil K Jain, Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, United States.
出版信息
World J Gastrointest Pathophysiol. 2016 Feb 15;7(1):38-47. doi: 10.4291/wjgp.v7.i1.38.
Abstract
The gastrointestinal tract (GIT) is a complex system, which changes in response to requirements of the body. GIT represents a barrier to the external environment. To achieve this, epithelial cells must renew rapidly. This renewal of epithelial cells starts in the fetal life under the influence of many GIT peptides by swallowing amniotic fluid (AF). Development and maturation of GIT is a very complex cascade that begins long before birth and continues during infancy and childhood by breast-feeding. Many factors like genetic preprogramming, local and systemic endocrine secretions and many trophic factors (TF) from swallowed AF contribute and modulate the development and growth of the GIT. GIT morphogenesis, differentiation and functional development depend on the activity of various TF in the AF. This manuscript will review the role of AF borne TF in the development of GIT.
摘要
胃肠道（GIT）是一个复杂的系统，会根据身体需求发生变化。胃肠道是对外界环境的一道屏障。为实现这一功能，上皮细胞必须快速更新。上皮细胞的这种更新始于胎儿期，在许多胃肠道肽的影响下，通过吞咽羊水（AF）来完成。胃肠道的发育和成熟是一个非常复杂的级联过程，早在出生前就开始了，并在婴儿期和儿童期通过母乳喂养持续进行。许多因素，如基因预编程、局部和全身内分泌分泌以及来自吞咽羊水的许多营养因子（TF），都对胃肠道的发育和生长起到促进和调节作用。胃肠道的形态发生、分化和功能发育取决于羊水中各种营养因子的活性。本手稿将综述羊水中携带的营养因子在胃肠道发育中的作用。
相似文献
1
Amniotic fluid: Source of trophic factors for the developing intestine.羊水：发育中肠道的营养因子来源。
World J Gastrointest Pathophysiol. 2016 Feb 15;7(1):38-47. doi: 10.4291/wjgp.v7.i1.38.
2
Systemic and luminal influences on the perinatal development of the gut.全身和管腔内因素对肠道围产期发育的影响。
Equine Vet J Suppl. 1997 Jun(24):40-50. doi: 10.1111/j.2042-3306.1997.tb05077.x.
3
Host factors in amniotic fluid and breast milk that contribute to gut maturation.羊水中和母乳中有助于肠道成熟的宿主因素。
Clin Rev Allergy Immunol. 2008 Apr;34(2):191-204. doi: 10.1007/s12016-007-8032-3.
4
Regulation of gastrointestinal growth in fetal sheep by luminally administered insulin-like growth factor-I.经肠腔给予胰岛素样生长因子-I对胎羊胃肠道生长的调节作用。
J Endocrinol. 1997 Jan;152(1):29-38. doi: 10.1677/joe.0.1520029.
5
The fetal gastrointestinal tract is exposed to melatonin and superoxide dismutase rich amniotic fluid throughout prenatal development.在整个产前发育过程中，胎儿胃肠道暴露于富含褪黑素和超氧化物歧化酶的羊水中。
J Clin Biochem Nutr. 2022 Jul;71(1):64-68. doi: 10.3164/jcbn.21-130. Epub 2022 Feb 15.
6
Medicinal Plants, Phytochemicals, and Their Impacts on the Maturation of the Gastrointestinal Tract.药用植物、植物化学物质及其对胃肠道成熟的影响。
Front Physiol. 2021 Jul 30;12:684464. doi: 10.3389/fphys.2021.684464. eCollection 2021.
7
Trophic effect of amniotic fluid on fetal gastrointestinal development.羊水对胎儿胃肠道发育的营养作用。
J Surg Res. 1986 Apr;40(4):291-6. doi: 10.1016/0022-4804(86)90189-7.
8
A comparative analysis of gastrointestinal tract barrier function and immune markers in gilt vs. sow progeny at birth and weaning.仔猪与母猪后代在出生和断奶时的胃肠道屏障功能和免疫标志物的比较分析。
J Anim Sci. 2024 Jan 3;102. doi: 10.1093/jas/skae054.
9
Can nutritional modulation of maternal intestinal microbiota influence the development of the infant gastrointestinal tract?营养调节母体肠道微生物群会影响婴儿胃肠道的发育吗？
J Nutr. 2012 Nov;142(11):1921-8. doi: 10.3945/jn.112.166231. Epub 2012 Sep 18.
10
The role of amniotic fluid in fetal nutrition.羊水在胎儿营养中的作用。
J Pediatr Surg. 1985 Dec;20(6):668-72. doi: 10.1016/s0022-3468(85)80021-x.
引用本文的文献
1
Meconium and Amniotic Fluid IgG Fc Binding Protein (FcGBP) Concentrations in Neonates Delivered by Cesarean Section and by Vaginal Birth in the Third Trimester of Pregnancy.妊娠晚期剖宫产和阴道分娩新生儿的胎粪及羊水免疫球蛋白G Fc结合蛋白（FcGBP）浓度
Int J Mol Sci. 2025 Aug 5;26(15):7579. doi: 10.3390/ijms26157579.
2
Amniotic fluid: its role in fetal development and beyond.羊水：其在胎儿发育及其他方面的作用。
J Perinatol. 2025 May 8. doi: 10.1038/s41372-025-02313-1.
3
Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery.用于羊膜腔内给药的聚合物纳米颗粒的蛋白质冠层和生物分布概况研究。
Biomaterials. 2025 Sep;320:123238. doi: 10.1016/j.biomaterials.2025.123238. Epub 2025 Mar 6.
4
Hour of Life at Enteral Feeding Initiation and Associated Clinical Morbidity in Extremely Low-Birth-Weight Infants.极低出生体重儿开始肠内喂养时的生命时长及相关临床发病率
Nutrients. 2024 Nov 26;16(23):4041. doi: 10.3390/nu16234041.
5
Microbiota-derived short chain fatty acids in pediatric health and diseases: from gut development to neuroprotection.微生物群衍生的短链脂肪酸在儿童健康与疾病中的作用：从肠道发育到神经保护
Front Microbiol. 2024 Oct 8;15:1456793. doi: 10.3389/fmicb.2024.1456793. eCollection 2024.
6
Evolutionary bridges: how factors present in amniotic fluid and human milk help mature the gut.进化之桥：羊水和人乳中存在的因子如何帮助肠道成熟。
J Perinatol. 2024 Nov;44(11):1552-1559. doi: 10.1038/s41372-024-02026-x. Epub 2024 Jun 6.
7
Exposure to the smell and taste of milk to accelerate feeding in preterm infants.接触牛奶的气味和味道以加速早产儿的喂养。
Cochrane Database Syst Rev. 2024 May 9;5(5):CD013038. doi: 10.1002/14651858.CD013038.pub3.
8
Factors Influencing Neonatal Gut Microbiome and Health with a Focus on Necrotizing Enterocolitis.影响新生儿肠道微生物群及健康的因素，重点关注坏死性小肠结肠炎
Microorganisms. 2023 Oct 10;11(10):2528. doi: 10.3390/microorganisms11102528.
9
The amniotic fluid proteome changes across gestation in humans and rhesus macaques.人类和食蟹猕猴妊娠过程中羊水中蛋白质组的变化。
Sci Rep. 2023 Oct 9;13(1):17039. doi: 10.1038/s41598-023-44125-3.
10
Microbiota and nutrition as risk and resiliency factors following prenatal alcohol exposure.产前酒精暴露后，微生物群和营养作为风险及恢复力因素
Front Neurosci. 2023 Jun 15;17:1182635. doi: 10.3389/fnins.2023.1182635. eCollection 2023.
本文引用的文献
1
Amniotic fluid-borne hepatocyte growth factor protects rat pups against experimental necrotizing enterocolitis.羊水中的肝细胞生长因子可保护大鼠幼仔免受实验性坏死性小肠结肠炎的影响。
Am J Physiol Gastrointest Liver Physiol. 2014 Mar 1;306(5):G361-9. doi: 10.1152/ajpgi.00272.2013. Epub 2014 Jan 9.
2
Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism.羊水干细胞通过 COX-2 依赖的机制改善坏死性小肠结肠炎受损肠道的存活率并增强其修复。
Gut. 2014 Feb;63(2):300-9. doi: 10.1136/gutjnl-2012-303735. Epub 2013 Mar 24.
3
Postnatal amniotic fluid intake reduces gut inflammatory responses and necrotizing enterocolitis in preterm neonates.产后摄入羊水可减轻早产儿肠道炎症反应和坏死性小肠结肠炎。
Am J Physiol Gastrointest Liver Physiol. 2013 May 15;304(10):G864-75. doi: 10.1152/ajpgi.00278.2012. Epub 2013 Mar 21.
4
Amniotic fluid-derived stem cells for cardiovascular tissue engineering applications.羊水来源的干细胞在心血管组织工程中的应用。
Tissue Eng Part B Rev. 2013 Aug;19(4):368-79. doi: 10.1089/ten.TEB.2012.0561. Epub 2013 Mar 14.
5
Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium.羊水可抑制胎儿和新生儿肠道上皮细胞中的 Toll 样受体 4 信号通路。
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11330-5. doi: 10.1073/pnas.1200856109. Epub 2012 Jun 25.
6
TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine.TGF-β2 抑制发育中肠道中巨噬细胞细胞因子的产生和黏膜炎症反应。
Gastroenterology. 2011 Jan;140(1):242-53. doi: 10.1053/j.gastro.2010.09.043. Epub 2010 Sep 24.
7
Host factors in amniotic fluid and breast milk that contribute to gut maturation.羊水中和母乳中有助于肠道成熟的宿主因素。
Clin Rev Allergy Immunol. 2008 Apr;34(2):191-204. doi: 10.1007/s12016-007-8032-3.
8
Into the unknown--the death pathways in the neonatal gut epithelium.
J Physiol Pharmacol. 2005 Jun;56 Suppl 3:7-24.
9
Amniotic fluid: not just fetal urine anymore.羊水：不再仅仅是胎儿的尿液了。
J Perinatol. 2005 May;25(5):341-8. doi: 10.1038/sj.jp.7211290.
10
Role of cytokines in human intestinal villous development.细胞因子在人类肠道绒毛发育中的作用。
Clin Perinatol. 2004 Mar;31(1):143-55. doi: 10.1016/j.clp.2004.03.003.
Zotero 插件