Fujimori I, Kikushima K, Goto R, Hisamatsu K, Murakami Y, Yamada T
Department of Otolaryngology, Yamanashi Medical University, Japan.
ORL J Otorhinolaryngol Relat Spec. 1996 May-Jun;58(3):147-50. doi: 10.1159/000276815.
A study was undertaken to evaluate the incidence of alpha-streptococci with inhibitory activity against pathogens, a defense mechanism of the normal flora against bacterial infection, in the nasopharynx and tonsils of 37 children with otitis media with effusion (OME). In the patients with OME, the detection rates of alpha-streptococci with inhibitory activity against Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus and group A streptococci in the nasopharynx were significantly lower than those of alpha-streptococci isolated from the tonsils. Furthermore, the detection rates of nasopharyngeal alpha-streptococci with inhibitory activity against H. influenzae and S. pneumoniae in OME patients were lower than those in patients with tonsillitis. In conclusion, low nasopharyngeal levels of alpha-streptococci with inhibitory activity against pathogens appear to render children susceptible to attacks of OME. We suggest that it is important to investigate the relationships between the prevalence of pathogens and the inhibitory activity of alpha-streptococci against them in the nasopharynx.
一项研究旨在评估37例分泌性中耳炎（OME）患儿鼻咽部和扁桃体中具有抗病原体抑制活性的α-链球菌的发生率，这是正常菌群抵抗细菌感染的一种防御机制。在OME患者中，鼻咽部对流感嗜血杆菌、肺炎链球菌、金黄色葡萄球菌和A组链球菌具有抑制活性的α-链球菌的检出率显著低于从扁桃体分离出的α-链球菌。此外，OME患者中对流感嗜血杆菌和肺炎链球菌具有抑制活性的鼻咽部α-链球菌的检出率低于扁桃体炎患者。总之，鼻咽部具有抗病原体抑制活性的α-链球菌水平较低似乎使儿童易患OME。我们认为，研究病原体的流行率与鼻咽部α-链球菌对它们的抑制活性之间的关系很重要。
