Fujimori I, Hisamatsu K, Kikushima K, Goto R, Murakami Y, Yamada T
Department of Otolaryngology, Yamanashi Medical University, Japan.
Eur Arch Otorhinolaryngol. 1996;253(4-5):260-3. doi: 10.1007/BF00171139.
A study was undertaken to evaluate the incidence of nasopharyngeal alpha-streptococci with inhibitory activity against pathogens, as a defense mechanism of the normal bacterial flora against infection. Cultures were taken from the nasopharynges of 43 children with otitis media with effusion (OME). The detection rates of alpha-streptococci with inhibitory activity against Haemophilus influenzae, Streptococcus pneumoniae, Staphylococus aureus and group A streptococci were significantly lower in the nasopharynx than those isolated from the tonsils of the same patients. Moreover, the detection rates of alpha-streptococci with inhibitory activity against all of these pathogens derived from the nasopharynx were lower than those in healthy children, streptococcal strains with activity against H. influenzae and Strep, pneumoniae were also lower than that in patients with tonsillitis. These findings suggest that low nasopharyngeal levels of alpha-streptococci with inhibitory activity against respiratory pathogens may render children susceptible to OME. Further studies are needed to investigate the relationships between the prevalence of pathogens in the nasopharynx and the inhibitory activities of alpha-streptococci against them in order to devise and select optimal treatment for patients with OME.
开展了一项研究，以评估具有抗病原体抑制活性的鼻咽部α-链球菌的发生率，作为正常细菌菌群抗感染的一种防御机制。从43例分泌性中耳炎（OME）患儿的鼻咽部采集培养物。具有抗流感嗜血杆菌、肺炎链球菌、金黄色葡萄球菌和A组链球菌抑制活性的α-链球菌在鼻咽部的检出率显著低于从同一患者扁桃体分离出的检出率。此外，来自鼻咽部的对所有这些病原体具有抑制活性的α-链球菌的检出率低于健康儿童，对流感嗜血杆菌和肺炎链球菌具有活性的链球菌菌株也低于扁桃体炎患者。这些发现表明，鼻咽部具有抗呼吸道病原体抑制活性的α-链球菌水平较低可能使儿童易患OME。需要进一步研究来调查鼻咽部病原体的流行率与α-链球菌对它们的抑制活性之间的关系，以便为OME患者设计和选择最佳治疗方法。
