Kondrat'eva O V, Stepanov V M
Antibiotiki. 1977 May;22(5):447-9.
Gentamicin sulfate was studied with an aim of obtaining mutants of the plague microbe with a changed character of requirements in the growth factors. The antibiotic provided a high yield of auxotrophic mutants and induced streptomycin resistance in some cells. Mutants with single dependence on arginine, leucine, histidine and uracyl were most often. Comparison of the data obtained with gentamicin and those obtained with other chemical mutagens showed that gentamicin by its mutagenic activity was only slightly inferior than the preparations of the group of supermutagens.
对硫酸庆大霉素进行了研究，目的是获得鼠疫微生物的突变体，使其对生长因子的需求特性发生改变。该抗生素产生了高产的营养缺陷型突变体，并在一些细胞中诱导出链霉素抗性。最常见的是对精氨酸、亮氨酸、组氨酸和尿嘧啶单一依赖的突变体。将用庆大霉素获得的数据与用其他化学诱变剂获得的数据进行比较表明，庆大霉素的诱变活性仅略低于超诱变剂组的制剂。
