Auranen A, Grénman S, Mäkinen J, Pukkala E, Sankila R, Salmi T
Department of Obstetrics and Gynecology, Turku University Hospital, Finland.
Am J Epidemiol. 1996 Sep 15;144(6):548-53. doi: 10.1093/oxfordjournals.aje.a008964.
A total of 1,197 borderline ovarian tumors were reported to the Finish Cancer Registry in 1973-1992. The mean age of the patients was 52 years, while the mean age of the 7,060 patients with an invasive epithelial ovarian carcinoma reported in the same time period was 62 years. The incidence of borderline ovarian tumors did not increase with age after patients became 35 years old and older. The overall age-adjusted incidence of borderline ovarian tumors was 1.8 per 100,000 women-years. Familial cancer occurrence during 1967-1992 was studied among relatives of 144 index patients diagnosed in 1980-1982. No borderline ovarian tumors were detected in the relatives, and only one of the 446 female first-degree relatives had an epithelial ovarian cancer. The expected number (borderline and invasive combined) was 1.9. The mothers of the index patients had an increased risk for pancreatic cancer (standardized incidence ratio 4.9, 95% confidence interval 1.0-14.3) and for cancer of the uterine cervix (standardized incidence ratio 7.8, 95% confidence interval 1.6-22.8). No significant increase in cancer risk was observed for fathers, brothers, or sisters of the patients with borderline ovarian tumors.
1973年至1992年期间，共有1197例卵巢交界性肿瘤报告给芬兰癌症登记处。患者的平均年龄为52岁，而在同一时期报告的7060例浸润性上皮性卵巢癌患者的平均年龄为62岁。卵巢交界性肿瘤的发病率在患者35岁及以上后并未随年龄增长而增加。卵巢交界性肿瘤的总体年龄调整发病率为每10万妇女年1.8例。对1980年至1982年确诊的144例索引患者的亲属在1967年至1992年期间的家族性癌症发生情况进行了研究。在亲属中未检测到卵巢交界性肿瘤，446名女性一级亲属中只有1人患有上皮性卵巢癌。预期数量（交界性和浸润性合并）为1.9例。索引患者的母亲患胰腺癌的风险增加（标准化发病率比为4.9，95%置信区间为1.0 - 14.3），患子宫颈癌的风险也增加（标准化发病率比为7.8，95%置信区间为1.6 - 22.8）。卵巢交界性肿瘤患者的父亲、兄弟或姐妹未观察到癌症风险有显著增加。
