Chiu N T, Weinstock M A
Dermatoepidemiology Unit, Veterans Affairs Medical Center, Providence, RI, USA.
Arch Otolaryngol Head Neck Surg. 1996 Sep;122(9):985-8. doi: 10.1001/archotol.1996.01890210057013.
To document the incidence and trends of oronasal melanoma with time, place, and person and to provide population-based estimates of survival and prognostic factors.
Descriptive analysis of 9 population-based cancer registries in the United States for the years 1973 to 1991.
All patients with primary melanoma of the oronasal mucosa who resided in the registry areas, which included approximately 10% of the US population.
None.
The incidence of oronasal melanoma was 0.041/10(5) per year. There were no significant race or gender differences in incidence. Melanomas of the nasal cavity were more common in the northern registry areas, and increased in incidence during the 19-year study period. Oral melanomas were less common in the North, and did not change significantly in incidence. The median survival with oronasal melanoma was 2 years, and the 5-year survival (+/- SE) was 25% (+/- 4%). Advanced age and stage were adverse prognostic features, but no significant differences in the prognosis were noted by anatomic subsite.
We have documented the incidence and prognosis of oronasal melanoma based on a large population-based sample. The prognosis is poor. The epidemiologic features differ substantially from those of cutaneous melanoma.
记录口鼻腔黑色素瘤的发病率及其随时间、地点和人群的变化趋势，并提供基于人群的生存率和预后因素估计。
对美国9个基于人群的癌症登记处1973年至1991年的数据进行描述性分析。
所有居住在登记地区的原发性口鼻腔黏膜黑色素瘤患者，这些地区人口约占美国总人口的10%。
无。
口鼻腔黑色素瘤的发病率为每年0.041/10⁵。发病率在种族和性别上无显著差异。鼻腔黑色素瘤在北部登记地区更为常见，在19年的研究期间发病率有所上升。口腔黑色素瘤在北方较少见，发病率无显著变化。口鼻腔黑色素瘤的中位生存期为2年，5年生存率（±标准误）为25%（±4%）。高龄和晚期是不良预后特征，但不同解剖部位的预后无显著差异。
我们基于大量人群样本记录了口鼻腔黑色素瘤的发病率和预后。预后较差。其流行病学特征与皮肤黑色素瘤有很大不同。
