Wattel E, Cavrois M, Gessain A, Wain-Hobson S
Service des Maladies du Sang, CHU, Lille, France.
J Acquir Immune Defic Syndr Hum Retrovirol. 1996;13 Suppl 1:S92-9. doi: 10.1097/00042560-199600001-00016.
Human T-cell lymphotropic virus type I (HTLV-I) is characterized by a remarkable genetic stability and high proviral loads in the absence of malignant disease. This results from the effect of tax on cell cycling. The virus replicates essentially in concert with the cell that is, via mitosis, which can be shown by polymerase chain reaction amplification of the HTLV-I integration sites. This is true of all stages of HTLV-I infection and accompanies adult T-cell leukemia/lymphoma. The very low viremia results from its genetic organization.
人类嗜T细胞病毒I型（HTLV-I）的特征是在无恶性疾病的情况下具有显著的遗传稳定性和高前病毒载量。这是由tax对细胞周期的影响导致的。该病毒基本上与细胞同步复制，即通过有丝分裂复制，这可以通过对HTLV-I整合位点进行聚合酶链反应扩增来证明。HTLV-I感染的所有阶段都是如此，并伴随着成人T细胞白血病/淋巴瘤。极低的病毒血症是由其基因结构导致的。
