Treisman J E, Rubin G M
MCB and HHMI, UC Berkeley, CA 94720, USA.
Mech Dev. 1996 May;56(1-2):17-24. doi: 10.1016/0925-4773(96)00508-4.
The Drosophila glass gene is required for the differentiation and survival of photoreceptors in the compound eye, ocelli and larval photoreceptor organ, glass encodes a zinc finger protein which can activate transcription in cell culture and is likely to act by regulating the expression of other genes. We have shown that it directly or indirectly controls the expression of approximately 25% of all enhancer trap lines expressed in the eye disc. glass gene activity is required to activate 19% of the lines, some of which express beta-galactosidase in photoreceptor subtype-specific patterns, and to repress 6%. The phenotype of eye discs doubly mutant for glass and the homeobox gene rough suggests that glass is required for subtype specification and for recruitment of cells to the ommatidial cluster.
果蝇的玻璃基因是复眼、单眼和幼虫光感受器器官中光感受器分化和存活所必需的，玻璃基因编码一种锌指蛋白，该蛋白可在细胞培养中激活转录，并且可能通过调节其他基因的表达发挥作用。我们已经表明，它直接或间接控制眼盘中表达的所有增强子陷阱系中约25%的表达。玻璃基因活性对于激活19%的系是必需的，其中一些系以光感受器亚型特异性模式表达β-半乳糖苷酶，并且对于抑制6%的系也是必需的。玻璃基因和同源框基因粗糙的双突变眼盘的表型表明，玻璃基因对于亚型特化以及将细胞募集到小眼簇是必需的。
