Doherty N S, Anttila M, Dean P B
Ann Rheum Dis. 1977 Jun;36(3):244-8. doi: 10.1136/ard.36.3.244.
Acute inflammation was induced in rats by subcutaneous implantation of plastic sponges, and the penetration of salicylate and naproxen into the inflammatory exudate was studied after oral dosing with these compounds. The penetration of intravenously administered 22Na and 125I-albumin was also studied. It was found that salicylate and 22Na penetrated very rapidly, reaching maximum concentration in the exudate within 3 hours of administration. In contrast, naproxen and 125I-albumin penetrated much more slowly, maximum concentrations in the exudates not being reached until 5 hours after administration. The significance of these results and the role of protein binding is discussed.
通过皮下植入塑料海绵在大鼠中诱导急性炎症，在口服给予这些化合物后研究水杨酸盐和萘普生进入炎性渗出液的渗透情况。还研究了静脉注射22Na和125I-白蛋白的渗透情况。发现水杨酸盐和22Na渗透非常迅速，给药后3小时内在渗出液中达到最大浓度。相比之下，萘普生和125I-白蛋白渗透要慢得多，直到给药后5小时才在渗出液中达到最大浓度。讨论了这些结果的意义以及蛋白质结合的作用。
