萘普生和水杨酸盐在大鼠体内向炎性渗出液的渗透。
Penetration of naproxen and salicylate into inflammatory exudates in the rat.
作者信息
Doherty N S, Anttila M, Dean P B
出版信息
Ann Rheum Dis. 1977 Jun;36(3):244-8. doi: 10.1136/ard.36.3.244.
Abstract
Acute inflammation was induced in rats by subcutaneous implantation of plastic sponges, and the penetration of salicylate and naproxen into the inflammatory exudate was studied after oral dosing with these compounds. The penetration of intravenously administered 22Na and 125I-albumin was also studied. It was found that salicylate and 22Na penetrated very rapidly, reaching maximum concentration in the exudate within 3 hours of administration. In contrast, naproxen and 125I-albumin penetrated much more slowly, maximum concentrations in the exudates not being reached until 5 hours after administration. The significance of these results and the role of protein binding is discussed.
摘要
通过皮下植入塑料海绵在大鼠中诱导急性炎症，在口服给予这些化合物后研究水杨酸盐和萘普生进入炎性渗出液的渗透情况。还研究了静脉注射22Na和125I-白蛋白的渗透情况。发现水杨酸盐和22Na渗透非常迅速，给药后3小时内在渗出液中达到最大浓度。相比之下，萘普生和125I-白蛋白渗透要慢得多，直到给药后5小时才在渗出液中达到最大浓度。讨论了这些结果的意义以及蛋白质结合的作用。
相似文献
1
Penetration of naproxen and salicylate into inflammatory exudates in the rat.萘普生和水杨酸盐在大鼠体内向炎性渗出液的渗透。
Ann Rheum Dis. 1977 Jun;36(3):244-8. doi: 10.1136/ard.36.3.244.
2
Naproxen metabolism in man.萘普生在人体内的代谢
J Clin Pharmacol. 1975 Apr;15(4 Pt. 2):316-23. doi: 10.1002/j.1552-4604.1975.tb01458.x.
3
Plasma and tissue kinetics of phenylbutazone and naproxen in dogs.犬体内保泰松和萘普生的血浆及组织动力学
Arch Int Pharmacodyn Ther. 1993 Sep-Oct;325:113-28.
4
Validity of calculation for the 131-I-albumin activity of leaking inflammatory oedema.渗出性炎症性水肿131-I-白蛋白活性计算的有效性。
Med Exp Int J Exp Med. 1969;19(1):42-51. doi: 10.1159/000137177.
5
Leaking of 131-I-albumin in the early phases of experimental inflammatory oedema.实验性炎性水肿早期131-I-白蛋白的渗漏
Med Exp Int J Exp Med. 1969;19(1):28-41. doi: 10.1159/000137176.
6
Pharmacokinetics of naproxen overdoses.萘普生过量的药代动力学。
Clin Pharmacol Ther. 1976 Sep;20(3):269-77. doi: 10.1002/cpt1976203269.
7
Meropenem pharmacokinetics and penetration into an inflammatory exudate.美罗培南的药代动力学及对炎性渗出液的穿透性。
Antimicrob Agents Chemother. 1990 Aug;34(8):1515-7. doi: 10.1128/AAC.34.8.1515.
8
[Investigations on the acute, carrageenan-induced inflammatory reaction and pharmacology of orally administered sodium salicylate in turkeys].[火鸡口服水杨酸钠对角叉菜胶诱导的急性炎症反应及药理学研究]
Berl Munch Tierarztl Wochenschr. 2015 May-Jun;128(5-6):240-51.
9
Penetration of nabumetone into inflammatory exudates in the rat.萘丁美酮在大鼠炎症渗出物中的渗透情况。
J Pharm Pharmacol. 1983 Jun;35(6):358-62. doi: 10.1111/j.2042-7158.1983.tb02956.x.
引用本文的文献
1
Naproxen treatment inhibits articular cartilage loss in a rat model of osteoarthritis.萘普生治疗可抑制骨关节炎大鼠模型的关节软骨丢失。
J Orthop Res. 2021 Oct;39(10):2252-2259. doi: 10.1002/jor.24937. Epub 2020 Dec 15.
2
Modeling Sex Differences in Pharmacokinetics, Pharmacodynamics, and Disease Progression Effects of Naproxen in Rats with Collagen-Induced Arthritis.萘普生对胶原诱导性关节炎大鼠药代动力学、药效学及疾病进展影响的性别差异建模
Drug Metab Dispos. 2017 May;45(5):484-491. doi: 10.1124/dmd.116.074526. Epub 2017 Feb 28.
3
Pharmacokinetics of nonsteroidal anti-inflammatory drugs in synovial fluid.非甾体抗炎药在滑液中的药代动力学
Clin Pharmacokinet. 1999 Mar;36(3):191-210. doi: 10.2165/00003088-199936030-00002.
4
Free plasma concentrations of piroxicam in patients with osteoarthritis: relation to age, sex and efficacy.骨关节炎患者血浆中吡罗昔康的游离浓度：与年龄、性别及疗效的关系。
Clin Rheumatol. 1993 Jun;12(2):226-30. doi: 10.1007/BF02231532.
5
The effects of D-pencillamine and levamisole on leucocyte chemotaxis in the rat.D-青霉胺和左旋咪唑对大鼠白细胞趋化性的影响。
Br J Pharmacol. 1978 May;63(1):119-23. doi: 10.1111/j.1476-5381.1978.tb07781.x.
6
Aspirin, salicylate and prostaglandins.阿司匹林、水杨酸盐与前列腺素。
Agents Actions. 1979 Dec;9(5-6):483-7. doi: 10.1007/BF01968116.
7
Aspirin and prostaglandins: some recent developments.阿司匹林与前列腺素：近期的一些进展
Agents Actions. 1978 Jun;8(4):427-9. doi: 10.1007/BF01968670.
本文引用的文献
1
INHIBITION OF PROTEIN DENATURATION BY ANTIRHEUMATIC OR ANTIPHLOGISTIC AGENTS.抗风湿或抗炎药物对蛋白质变性的抑制作用。
Arch Int Pharmacodyn Ther. 1964 May 1;149:1-7.
2
SIMULTANEOUS SALICYLATE CONCENTRATIONS IN SYNOVIAL FLUID AND PLASMA IN RHEUMATOID ARTHRITIS.类风湿关节炎患者滑液和血浆中水杨酸盐的同步浓度
Arthritis Rheum. 1964 Apr;7:103-9. doi: 10.1002/art.1780070202.
3
A fluorometric method for direct determination of total salicylate in plasma.一种直接测定血浆中总水杨酸盐的荧光法。
Pharm Acta Helv. 1971 Oct-Nov;46(10):632-6.
4
5
Simultaneous pharmacokinetics of indomethacin in serum and synovial fluid.吲哚美辛在血清和滑液中的同步药代动力学。
Ann Rheum Dis. 1973 Sep;32(5):433-5. doi: 10.1136/ard.32.5.433.
6
The displacement of L-tryptophan and dipeptides from bovine albumin in vitro and from human plasma in vivo by antirheumatic drugs.抗风湿药物在体外从牛白蛋白以及在体内从人血浆中置换L-色氨酸和二肽的情况。
J Pharm Pharmacol. 1971 Jun;23(6):393-8. doi: 10.1111/j.2042-7158.1971.tb08669.x.
7
Stabilization of erythrocyte membrane by non-steroianti-inflammatory drugs.非甾体抗炎药对红细胞膜的稳定作用
J Pharm Pharmacol. 1969 May;21(5):327-8. doi: 10.1111/j.2042-7158.1969.tb08260.x.
8
Drugs which inhibit prostaglandin biosynthesis.抑制前列腺素生物合成的药物。
Pharmacol Rev. 1974 Mar;26(1):33-67.
9
Binding of drugs to serum albumin (first of two parts).药物与血清白蛋白的结合（两部分中的第一部分）
N Engl J Med. 1976 Feb 5;294(6):311-6. doi: 10.1056/NEJM197602052940605.
10
Acidic nonsteroid anti-inflammatory drugs accumulating in inflamed tissue.酸性非甾体抗炎药在炎症组织中蓄积。
Experientia. 1975 Aug 15;31(8):951-3. doi: 10.1007/BF02358871.
Zotero 插件