Cunningham F M, Ford-Hutchinson A W, Oliver A M, Smith M J, Walker J R
Br J Pharmacol. 1978 May;63(1):119-23. doi: 10.1111/j.1476-5381.1978.tb07781.x.
The administration of D-penicillamine (25 mg/kg) or levamisole (5 mg/kg) had no effect on leucocyte emigration into the exudates formed in inert sponges implanted in normal rats. 2 In rats, previously sensitized to Bordetella pertussis and implanted with sponges containing pertussis vaccine, an increased leucocyte migration into the exudates occurred; this was significantly enhanced by the administration of the drugs. 3 Neither drug in vitro affected the chemotaxis of rat polymorphonuclear leucocytes although random migration was significantly increased by levamisole (2 microgram to 1 mg/ml). Neither drug affected the chemotaxis of rat mononuclear cells although levamisole (25 microgram/ml) significantly increased that of human monocytes. 4 It is concluded that both drugs produce similar effects in an animal model of delayed hypersensitivity and that their clinical antirheumatic actions may have common elements.
给予D-青霉胺（25毫克/千克）或左旋咪唑（5毫克/千克）对正常大鼠植入惰性海绵后形成的渗出液中的白细胞渗出没有影响。2在预先对百日咳博德特氏菌致敏并植入含有百日咳疫苗的海绵的大鼠中，进入渗出液的白细胞迁移增加；药物给药显著增强了这种迁移。3两种药物在体外均不影响大鼠多形核白细胞的趋化性，尽管左旋咪唑（2微克至1毫克/毫升）显著增加了随机迁移。两种药物均不影响大鼠单核细胞的趋化性，尽管左旋咪唑（25微克/毫升）显著增加了人单核细胞的趋化性。4得出的结论是，两种药物在迟发型超敏反应动物模型中产生相似的作用，并且它们的临床抗风湿作用可能有共同的因素。
