Sandler M P, Patton J A
Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tenn. 37232-2675, USA.
J Nucl Cardiol. 1996 Jul-Aug;3(4):342-9. doi: 10.1016/s1071-3581(96)90095-1.
The identification of hibernating myocardium in patients with poor ventricular function has become increasingly important as investigators demonstrate an improvement in ventricular performance in patients with injured but viable myocardium who undergo surgical revascularization. Modifications of 201Tl redistribution protocols and rest/stress 99mTc-labeled hexakis-2-methoxy-2-methyl propylisonitrile perfusion studies continue to underestimate myocardial viability compared with resting 18F-labeled fluorodeoxyglucose (18FDG) positron emission tomography. The combined data from multiple investigators suggest that 18FDG single-photon emission computed tomography used in combination with cardiac perfusion agents, either sequentially or with simultaneous dual-isotope acquisition, may provide an acceptable alternative to positron emission tomographic imaging for the detection of hibernating myocardium.
随着研究人员证实，接受外科血管重建术的心肌受损但仍存活的患者，其心室功能有所改善，因此，识别心室功能不佳患者的冬眠心肌变得越来越重要。与静息状态下的18F标记的氟脱氧葡萄糖（18FDG）正电子发射断层扫描相比，201Tl再分布方案以及静息/负荷99mTc标记的六甲氧基-2-甲基丙基异腈灌注研究的改进方法，仍会低估心肌活力。来自多个研究人员的综合数据表明，18FDG单光子发射计算机断层扫描与心脏灌注剂联合使用，无论是序贯使用还是同时进行双同位素采集，都可能为检测冬眠心肌提供一种可接受的正电子发射断层扫描成像替代方法。
