Jain Diwakar, He Zuo-Xiang, Lele Vikram, Aronow Wilbert S
Cardiovascular Nuclear Imaging Laboratory, New York Medical College, Westchester Medical Center, Valhalla, New York.
Clin Cardiol. 2015 Feb;38(2):124-30. doi: 10.1002/clc.22346. Epub 2014 Dec 8.
Myocardial perfusion imaging (MPI), using radiotracers, has been in routine clinical use for over 40 years. This modality is used for the detection of coronary artery disease (CAD), risk stratification, optimizing therapy, and follow-up of patients with CAD. Molecular cardiovascular imaging using targeted radiotracers provides a unique opportunity for imaging biochemical and metabolic processes, and cell membrane transporter and receptor functions at a cellular and molecular level in experimental animal models as well as in humans. Cardiac imaging using radiolabeled free fatty acid analogues and glucose analogues enable us to image myocardial ischemia directly as an alternative to stress-rest MPI. Direct ischemia imaging techniques can avoid and overcome some of the limitations of standard stress-rest MPI. This article describes recent studies using (18) F-fluorodeoxyglucose ((18) FDG) for myocardial ischemia imaging.
使用放射性示踪剂的心肌灌注成像（MPI）已在临床常规应用超过40年。这种检查方法用于检测冠状动脉疾病（CAD）、风险分层、优化治疗以及对CAD患者进行随访。使用靶向放射性示踪剂的分子心血管成像为在实验动物模型以及人类中在细胞和分子水平对生化和代谢过程、细胞膜转运体和受体功能进行成像提供了独特的机会。使用放射性标记的游离脂肪酸类似物和葡萄糖类似物进行心脏成像使我们能够直接对心肌缺血进行成像作为负荷-静息MPI的替代方法。直接缺血成像技术可以避免和克服标准负荷-静息MPI的一些局限性。本文描述了使用（18）F-氟脱氧葡萄糖（（18）FDG）进行心肌缺血成像的近期研究。
