佐剂MPL + TDM对B16小鼠黑色素瘤模型中肿瘤攻击的影响。
Effects of the adjuvant MPL + TDM on tumor challenge in the B16 mouse melanoma model.
作者信息
Price J A, McGee J M, Patten M R, Snyder D
机构信息
Department of Biochemistry and Microbiology, College of Osteopathic Medicine, Oklahoma State University, Tulsa 74107, USA.
出版信息
Int J Immunopharmacol. 1996 Feb;18(2):163-5. doi: 10.1016/0192-0561(96)00003-3.
PMID:8799366
Abstract
Mice were injected three times at 2 week intervals with the adjuvant MPL + TDM or phosphate-buffered saline. Two weeks after the last injection, all mice were challenged subcutaneously with a tumorgenic dose of B16 tumor and observed for 40 days. The adjuvant hastened the time at which tumors appeared (P = 0.02).
摘要
每隔2周给小鼠注射3次佐剂MPL + TDM或磷酸盐缓冲盐水。最后一次注射后2周，所有小鼠皮下注射致瘤剂量的B16肿瘤并观察40天。该佐剂缩短了肿瘤出现的时间（P = 0.02）。
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