对疟疾传播阻断疫苗候选抗原的佐剂依赖性免疫反应。
Adjuvant-dependent immune response to malarial transmission-blocking vaccine candidate antigens.
作者信息
Rawlings D J, Kaslow D C
机构信息
Molecular Vaccine Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
出版信息
J Exp Med. 1992 Nov 1;176(5):1483-7. doi: 10.1084/jem.176.5.1483.
Abstract
Immune responses in major histocompatibility complex (MHC)-disparate congenic mouse strains immunized with sexual stage malaria parasites or purified recombinant protein were adjuvant dependent. Whereas mice exhibited a limited antibody response to immunization with newly emerged Plasmodium falciparum gametes in Freund's adjuvant, all five congenic mouse strains responded to several transmission-blocking vaccine candidate antigens, when parasites were emulsified in a monophosphoryl lipid A (MPL) and trehalose dimycolate (TDM) adjuvant. The humoral response in those animals immunized with the antigen in a MPL/TDM adjuvant was helper T cell dependent, as evident by boosting of the antibody response after a second immunization. If the immunogen consisted of purified recombinant protein, then the immune response was not MHC class II limited in mice immunized with either complete Freund's adjuvant or TDM/MPL. The potential role of adjuvants in overcoming apparent immune nonresponsiveness and the implications for development of a malaria transmission-blocking vaccine are discussed.
摘要
用有性期疟原虫或纯化重组蛋白免疫主要组织相容性复合体（MHC）不同的同基因小鼠品系时，免疫反应依赖于佐剂。在用弗氏佐剂免疫新出现的恶性疟原虫配子时，小鼠表现出有限的抗体反应，而当寄生虫在单磷酰脂质A（MPL）和海藻糖二霉菌酸酯（TDM）佐剂中乳化时，所有五个同基因小鼠品系对几种传播阻断疫苗候选抗原均有反应。用MPL/TDM佐剂中的抗原免疫的那些动物的体液反应依赖于辅助性T细胞，第二次免疫后抗体反应增强就证明了这一点。如果免疫原由纯化的重组蛋白组成，那么在用完全弗氏佐剂或TDM/MPL免疫的小鼠中，免疫反应不受MHC II类限制。讨论了佐剂在克服明显免疫无反应性方面的潜在作用以及对疟疾传播阻断疫苗开发的影响。
相似文献
1
Adjuvant-dependent immune response to malarial transmission-blocking vaccine candidate antigens.对疟疾传播阻断疫苗候选抗原的佐剂依赖性免疫反应。
J Exp Med. 1992 Nov 1;176(5):1483-7. doi: 10.1084/jem.176.5.1483.
2
Lipopeptide immunization without adjuvant induces potent and long-lasting B, T helper, and cytotoxic T lymphocyte responses against a malaria liver stage antigen in mice and chimpanzees.无佐剂脂肽免疫诱导小鼠和黑猩猩针对疟疾肝期抗原产生强效且持久的B细胞、辅助性T细胞和细胞毒性T淋巴细胞应答。
Eur J Immunol. 1997 May;27(5):1242-53. doi: 10.1002/eji.1830270528.
3
Comparison of BCG, MPL and cationic liposome adjuvant systems in leishmanial antigen vaccine formulations against murine visceral leishmaniasis.BCG、MPL 和阳离子脂质体佐剂系统在抗内脏利什曼病的利什曼原虫抗原疫苗配方中的比较。
BMC Microbiol. 2010 Jun 24;10:181. doi: 10.1186/1471-2180-10-181.
4
5
Liposomes containing lipid A: a potent nontoxic adjuvant for a human malaria sporozoite vaccine.含脂质A的脂质体：一种用于人类疟疾子孢子疫苗的高效无毒佐剂。
Immunol Lett. 1990 Aug;25(1-3):275-9. doi: 10.1016/0165-2478(90)90127-c.
6
Vaccination with liposomal leishmanial antigens adjuvanted with monophosphoryl lipid-trehalose dicorynomycolate (MPL-TDM) confers long-term protection against visceral leishmaniasis through a human administrable route.用脂质体利什曼原虫抗原与单磷酰脂质-海藻糖二脂（MPL-TDM）佐剂免疫接种，通过可人类给药途径对内脏利什曼病提供长期保护。
Mol Pharm. 2012 Jan 1;9(1):59-70. doi: 10.1021/mp2002494. Epub 2011 Dec 14.
7
Murine immune responses to liver-stage antigen 1 protein FMP011, a malaria vaccine candidate, delivered with adjuvant AS01B or AS02A.小鼠对肝期抗原1蛋白FMP011（一种疟疾疫苗候选物）与佐剂AS01B或AS02A联合使用时的免疫反应。
Infect Immun. 2007 Feb;75(2):838-45. doi: 10.1128/IAI.01075-06. Epub 2006 Nov 13.
8
Vaccination with toxofilin DNA in combination with an alum-monophosphoryl lipid A mixed adjuvant induces significant protective immunity against Toxoplasma gondii.用弓形虫亲环蛋白DNA与明矾-单磷酰脂质A混合佐剂联合接种可诱导出显著的抗刚地弓形虫保护性免疫。
BMC Infect Dis. 2017 Jan 5;17(1):19. doi: 10.1186/s12879-016-2147-1.
9
Use of adjuvant containing mycobacterial cell-wall skeleton, monophosphoryl lipid A, and squalane in malaria circumsporozoite protein vaccine.
Lancet. 1991 Apr 27;337(8748):998-1001. doi: 10.1016/0140-6736(91)92659-p.
10
Nasal immunization with a malaria transmission-blocking vaccine candidate, Pfs25, induces complete protective immunity in mice against field isolates of Plasmodium falciparum.用一种疟疾传播阻断候选疫苗Pfs25进行鼻腔免疫，可在小鼠中诱导出针对恶性疟原虫野外分离株的完全保护性免疫。
Infect Immun. 2005 Nov;73(11):7375-80. doi: 10.1128/IAI.73.11.7375-7380.2005.
引用本文的文献
1
Inflammatory Responses Potentiate GAS M Protein Induced Cardiac Damage in an Experimental Model of Rheumatic Heart Disease.在风湿性心脏病实验模型中，炎症反应增强A群链球菌M蛋白诱导的心脏损伤。
Immun Inflamm Dis. 2025 Jul;13(7):e70221. doi: 10.1002/iid3.70221.
2
Improved protection against Chlamydia muridarum using the native major outer membrane protein trapped in Resiquimod-carrying amphipols and effects in protection with addition of a Th1 (CpG-1826) and a Th2 (Montanide ISA 720) adjuvant.利用被 Resiquimod 包裹的天然主要外膜蛋白制备的 Amphipols 提高对鼠型衣原体的保护作用，以及添加 Th1（CpG-1826）和 Th2（Montanide ISA 720）佐剂的保护效果。
Vaccine. 2020 Jun 9;38(28):4412-4422. doi: 10.1016/j.vaccine.2020.04.065. Epub 2020 Apr 30.
3
Complete Freund's adjuvant induces experimental autoimmune myocarditis by enhancing IL-6 production during initiation of the immune response.完全弗氏佐剂通过增强免疫反应起始时的 IL-6 产生来诱导实验性自身免疫性心肌炎。
Immun Inflamm Dis. 2017 Jun;5(2):163-176. doi: 10.1002/iid3.155. Epub 2017 Mar 13.
4
STAT4 is required for the generation of Th1 and Th2, but not Th17 immune responses during monophosphoryl lipid A adjuvant activity.在单磷酰脂质A佐剂活性过程中，STAT4是产生Th1和Th2免疫反应所必需的，但不是产生Th17免疫反应所必需的。
Int Immunol. 2016 Nov;28(11):565-570. doi: 10.1093/intimm/dxw038. Epub 2016 Aug 30.
5
Adjuvants in the Driver's Seat: How Magnitude, Type, Fine Specificity and Longevity of Immune Responses Are Driven by Distinct Classes of Immune Potentiators.掌控全局的佐剂：不同类型的免疫增强剂如何驱动免疫反应的强度、类型、精细特异性和持久性
Vaccines (Basel). 2014 Apr 10;2(2):252-96. doi: 10.3390/vaccines2020252.
6
Generation of humoral immune responses to multi-allele PfAMA1 vaccines; effect of adjuvant and number of component alleles on the breadth of response.多等位基因 PfAMA1 疫苗诱导体液免疫应答；佐剂和成分等位基因数量对反应广度的影响。
PLoS One. 2010 Nov 3;5(11):e15391. doi: 10.1371/journal.pone.0015391.
7
Regulation of CD4 T-cell receptor diversity by vaccine adjuvants.疫苗佐剂对 CD4 T 细胞受体多样性的调节。
Immunology. 2010 May;130(1):16-22. doi: 10.1111/j.1365-2567.2010.03265.x. Epub 2010 Mar 17.
8
Biological activities of anti-merozoite surface protein-1 antibodies induced by adjuvant-assisted immunizations in mice with different immune gene knockouts.在不同免疫基因敲除小鼠中，佐剂辅助免疫诱导产生的抗裂殖子表面蛋白-1抗体的生物学活性。
Clin Vaccine Immunol. 2008 Aug;15(8):1145-50. doi: 10.1128/CVI.00058-08. Epub 2008 Jun 18.
9
Interleukin-6 has differential influence on the ability of adjuvant formulations to potentiate antibody responses to a Plasmodium falciparum blood-stage vaccine.白细胞介素-6对佐剂配方增强针对恶性疟原虫血液期疫苗的抗体反应的能力具有不同影响。
Vaccine. 2007 Sep 4;25(36):6598-603. doi: 10.1016/j.vaccine.2007.06.057. Epub 2007 Jul 19.
10
Plasmodium p25 and p28 surface proteins: potential transmission-blocking vaccines.疟原虫p25和p28表面蛋白：潜在的传播阻断疫苗。
Eukaryot Cell. 2007 Aug;6(8):1260-5. doi: 10.1128/EC.00060-07. Epub 2007 Jun 8.
本文引用的文献
1
Complete in vitro maturation of Plasmodium falciparum gametocytes.恶性疟原虫配子体的完全体外成熟
Nature. 1981 Nov 26;294(5839):364-6. doi: 10.1038/294364a0.
2
Beneficial modification of the endotoxin molecule.内毒素分子的有益修饰
J Biol Response Mod. 1984;3(1):1-9.
3
Target antigens of transmission-blocking immunity on gametes of plasmodium falciparum.恶性疟原虫配子体上传播阻断免疫的靶抗原
J Exp Med. 1983 Sep 1;158(3):976-81. doi: 10.1084/jem.158.3.976.
4
Biologically active components from mycobacterial cell walls. I. Isolation and composition of cell wall skeleton and component P3.分枝杆菌细胞壁的生物活性成分。I. 细胞壁骨架和成分P3的分离与组成
J Natl Cancer Inst. 1974 Jan;52(1):95-101. doi: 10.1093/jnci/52.1.95.
5
Immunization with antigen and interleukin 2 in vivo overcomes Ir gene low responsiveness.在体内用抗原和白细胞介素2进行免疫可克服Ir基因低反应性。
J Exp Med. 1985 Jul 1;162(1):381-6. doi: 10.1084/jem.162.1.381.
6
7
Natural and synthetic trehalose diesters as immunomodulators.天然和合成海藻糖二酯作为免疫调节剂。
Med Res Rev. 1986 Jul-Sep;6(3):243-74. doi: 10.1002/med.2610060302.
8
Genetic analysis of the human malaria parasite Plasmodium falciparum.人类疟原虫恶性疟原虫的基因分析。
Science. 1987 Jun 26;236(4809):1661-6. doi: 10.1126/science.3299700.
9
Antibodies to Plasmodium falciparum gamete surface antigens in Papua New Guinea sera.巴布亚新几内亚血清中针对恶性疟原虫配子表面抗原的抗体。
Parasite Immunol. 1988 Mar;10(2):209-18. doi: 10.1111/j.1365-3024.1988.tb00215.x.
10
Parasite polymorphism present within minimal T cell epitopes of Plasmodium falciparum circumsporozoite protein.
J Immunol. 1988 Mar 1;140(5):1645-50.
Zotero 插件