3-磷酸甘油醛脱氢酶与网织红细胞膜关联的进一步特征研究。
Further characterization of the association of glyceraldehyde-3-phosphate dehydrogenase with reticulocyte membranes.
作者信息
Letko G, Bohnensack R
出版信息
Acta Biol Med Ger. 1975;34(7):1145-51.
PMID:880
Abstract
- The behaviour and properties of membrane-bound GAPDH of rabbit reticulocytes were investigated. 2. The bound GAPDH is more resistant to inactivation by KCl than the soluble enzyme (allotopy). 3. The bound enzyme is released by electrolytes. This effect does not only depend on the ionic strength but additionally on the kind of ions, pH-value and protein concentration. 4. A comparison of the releasing effect of NAD analogues shows the necessity of the 5'-AMP moiety in the structure of the effector. 5. The represented results demonstrate the specifity of the GAPDH-membrane binding in rabbit reticulocytes.
摘要
- 对兔网织红细胞膜结合型甘油醛-3-磷酸脱氢酶（GAPDH）的行为和特性进行了研究。2. 结合型GAPDH比可溶性酶更耐KCl失活（异位性）。3. 结合型酶可被电解质释放。这种效应不仅取决于离子强度，还取决于离子种类、pH值和蛋白质浓度。4. 对NAD类似物释放效应的比较表明效应物结构中5'-AMP部分的必要性。5. 所示结果证明了兔网织红细胞中GAPDH与膜结合的特异性。
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