Jalife J, Gray R
Department of Pharmacology, SUNY Health Science Center at Syracuse 13210, USA.
Acta Physiol Scand. 1996 Jun;157(2):123-31. doi: 10.1046/j.1365-201X.1996.505249000.x.
Ventricular fibrillation is the most important cause of cardiac electrical instability leading to sudden death. Fibrillation is believed to be associated with complex three-dimensional (3-D) spatio-temporal patterns of electrical excitation of the myocardium. However, to this date, such patterns have not been directly observed or characterized, and little is known about their dynamics. In this paper, we present results that strongly support the hypothesis that at least some cases of ventricular fibrillation in the structurally normal heart may be the result of a single 3-D electrical scroll wave that moves rapidly throughout the ventricles, giving rise to complex patterns of cardiac muscle excitation.
心室颤动是导致心源性猝死的心脏电不稳定的最重要原因。颤动被认为与心肌电兴奋的复杂三维时空模式有关。然而，迄今为止，尚未直接观察到或描述过这种模式，对其动态变化也知之甚少。在本文中，我们展示的结果有力地支持了以下假设：在结构正常的心脏中，至少某些心室颤动的情况可能是单个三维电涡旋波在整个心室中快速移动的结果，从而产生复杂的心肌兴奋模式。
