Souliez L, Pasquier F, Lebert F, Leconte P, Petit H
UFR de Psychologie, Universitè de Lille 3, France.
Cortex. 1996 Jun;32(2):347-56. doi: 10.1016/s0010-9452(96)80056-6.
Memory deficit is the predominant presenting symptom in dementia. To compare short-term memory (STM) deficit in early dementia of Alzheimer type (DAT) vs frontal lobe type (DFT), and determine the residual memory capacity for stimulation, the generation effect (the memory advantage of items generated rather than read) was tested on verbal and visuospatial STM in patients with DAT (n = 10), DFT (n = 9) and in age-matched normal controls (n = 12). The generation effect enhanced performance in all groups. However, the profile of STM deficit differed in the two dementias: verbal and visuospatial memory were both decreased in DAT vs verbal memory only in DFT. These results provide a further criterion for differentiating between DAT and DFT, and show that memory performance can be enhanced in early dementia using techniques such as the generation effect.
记忆缺陷是痴呆症的主要症状。为比较阿尔茨海默型（DAT）早期痴呆与额叶型（DFT）早期痴呆的短期记忆（STM）缺陷，并确定刺激后的残余记忆能力，对10例DAT患者、9例DFT患者和12例年龄匹配的正常对照者进行了言语和视觉空间STM的生成效应（生成项目而非阅读项目的记忆优势）测试。生成效应提高了所有组的表现。然而，两种痴呆症的STM缺陷特征有所不同：DAT患者的言语和视觉空间记忆均下降，而DFT患者仅言语记忆下降。这些结果为区分DAT和DFT提供了进一步的标准，并表明使用生成效应等技术可以提高早期痴呆症患者的记忆表现。
