Cebrat M, Wieczorek Z, Siemion I Z
Institute of Chemistry, University of Wroclaw, Poland.
Peptides. 1996;17(2):191-6. doi: 10.1016/0196-9781(95)02123-x.
Hymenistatin I (HS-I), a cyclic octapeptide [c-(-Pro-Pro-Tyr-Val-Pro-Leu-Ile-Ile-)], was synthesized by the solid-phase peptide synthesis method and examined for its immunosuppressive activity in the humoral and cellular immune responses. The peptide activity was tested on cell lines producing various cytokines. The results are compared with the activity of the well-known immunosuppressive agent cyclosporin A (CsA). It was found that hymenistatin I exerts immunosuppressive effect (both in the humoral and cellular immune responses) comparable with that of CsA. Comparison of the influence of HS-I and CsA on cytokines production suggests that the mechanisms of the interaction with the immunological system are substantially different for the two compounds tested.
膜翅菌素I（HS-I），一种环八肽[c-(-脯氨酸-脯氨酸-酪氨酸-缬氨酸-脯氨酸-亮氨酸-异亮氨酸-异亮氨酸-)]，通过固相肽合成法合成，并检测了其在体液免疫和细胞免疫反应中的免疫抑制活性。该肽的活性在产生各种细胞因子的细胞系上进行了测试。结果与著名的免疫抑制剂环孢素A（CsA）的活性进行了比较。发现膜翅菌素I在体液免疫和细胞免疫反应中均发挥出与CsA相当的免疫抑制作用。HS-I和CsA对细胞因子产生影响的比较表明，所测试的这两种化合物与免疫系统相互作用的机制有很大不同。
