CCKA受体激动剂A71378与CCK-8S的饱腹感效应比较。

Comparison of the satiating effect of the CCKA receptor agonist A71378 with CCK-8S.

作者信息

Voits M, Voigt J P, Boomgaarden M, Henklein P, Fink H

机构信息

Institute of Pharmacology and Toxicology, Charité, Medical Faculty of the Humboldt University, Berlin, Germany.

出版信息

Peptides. 1996;17(2):355-7. doi: 10.1016/0196-9781(95)02131-0.

DOI:10.1016/0196-9781(95)02131-0

PMID:8801546

Abstract

The satiating effect of the selective cholecystokininA (CCKA) receptor agonist A71378 and the mixed A and B receptor agonist CCK-8S were compared in 24-h food-deprived rats. After systemic application of 1.6, 8.0, and 40 micrograms/kg A71378 or CCK-8S, respectively, food intake was measured for 24 h. During the first hour A71378 and CCK-8S decreased food intake similarly. Two and 4 h after treatment, the satiating effect of A71378 continued. In contrast, 2 h after administration of CCK-8S a slight effect was observed at the highest dose (40 micrograms/kg), which totally disappeared after 4 h. In summary, the effect of A71378 on food intake is longer lasting compared to CCK-8S.

摘要

在禁食24小时的大鼠中比较了选择性胆囊收缩素A（CCKA）受体激动剂A71378和A、B型混合受体激动剂CCK-8S的饱腹感作用。分别全身应用1.6、8.0和40微克/千克的A71378或CCK-8S后，测量24小时的食物摄入量。在最初的一小时内，A71378和CCK-8S对食物摄入量的降低作用相似。治疗后2小时和4小时，A71378的饱腹感作用持续存在。相比之下，给予CCK-8S 2小时后，在最高剂量（40微克/千克）时观察到轻微作用，4小时后完全消失。总之，与CCK-8S相比，A71378对食物摄入的作用持续时间更长。