Voits M, Förster S, Rödel S, Voigt J P, Plagemann A, Fink H
Institut für Pharmakologie and Toxikologie, Charité, Medizinische Fakultät der Humboldt Universität zu Berlin, Germany.
Naunyn Schmiedebergs Arch Pharmacol. 1996 Aug-Sep;354(3):374-8. doi: 10.1007/BF00171071.
The response to cholecystokinin (CCK) as a satiety peptide in obesity or anorexia has been tested mainly in extreme models of food intake control. In the present study, the effect of CCK-8S on food intake was investigated in a nongenetic and less-stressful model of obesity due to unspecific early postnatal overfeeding in male and female rats. Reducing the normal litter size of ten to three newborn rats on day 3 of life led to an enhanced food intake resulting in an increased body weight until adulthood. Freely fed male and female, normal and obese rats were given 10 micrograms/kg CCK-8S i.p. on day 41 and 40 micrograms/kg CCK-8S on day 91 of life and food intake was measured for 24 h. Compared with treatment with saline (i.p.) 1 day before the test, the lower dose of 10 micrograms/kg CCK-8S reduced food intake for 2 h in normal, but not in obese rats. Conversely, the higher dose of 40 micrograms/kg CCK-8S reduced food intake in both normal and obese rats for 2 h, but this effect was more evident in the obese rats. Moreover, the satiating effect of CCK-8S was more pronounced and longer lasting in male than in female rats. In summary, the data suggest that the response to CCK-8S differs in normal and obese rats and depends on sex.
胆囊收缩素（CCK）作为一种饱腹感肽，在肥胖或厌食症中对食物摄入的反应主要在极端的食物摄入控制模型中进行了测试。在本研究中，在雄性和雌性大鼠因出生后早期非特异性过度喂养导致的非遗传性且压力较小的肥胖模型中，研究了CCK-8S对食物摄入的影响。在出生后第3天将正常的每窝10只新生大鼠减少至3只，导致食物摄入量增加，直至成年体重增加。在出生后第41天，对自由进食的雄性和雌性正常及肥胖大鼠腹腔注射10微克/千克CCK-8S，在出生后第91天注射40微克/千克CCK-8S，并测量24小时的食物摄入量。与测试前1天腹腔注射生理盐水相比，较低剂量的10微克/千克CCK-8S可使正常大鼠的食物摄入量减少2小时，但对肥胖大鼠无效。相反，较高剂量的40微克/千克CCK-8S可使正常和肥胖大鼠的食物摄入量均减少2小时，但这种作用在肥胖大鼠中更明显。此外，CCK-8S的饱腹感作用在雄性大鼠中比在雌性大鼠中更明显且持续时间更长。总之，数据表明正常和肥胖大鼠对CCK-8S的反应不同，且取决于性别。
